Nitric oxide enhancement strategies.
Nitric oxide enhancement strategies.
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DOI：
10.4155/fso.15.48
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发表时间：
2015-08
影响因子：
2.5
通讯作者：
Bryan NS
中科院分区：
文献类型：
--
作者：
Bryan NS
越来越清楚的是，许多疾病的特征在于或与一氧化氮（NO）产生/信号传导的扰动有关。旨在恢复正常NO稳态的治疗或策略可能具有广泛的应用和效用。这种高度复杂的和多步骤的NO生产和随后的目标激活的途径提供了许多步骤的内源性途径，可能是有用的目标，用于心血管疾病，抗菌，癌症，伤口愈合等药物开发本文将总结已知的策略，目前可用或在开发中，用于提高NO的生产或可用性在人体内。每种策略将被讨论，包括NO的外源性来源，使用前体，以促进NO的生产和下游途径受NO生产的优势和劣势突出每个。基于NO的治疗方法的开发是并将继续是生物技术，学术界以及制药公司的主要焦点。采用安全有效的战略必将改变健康和疾病状况。
It is becoming increasingly clear that many diseases are characterized or associated with perturbations in nitric oxide (NO) production/signaling. Therapeutics or strategies designed to restore normal NO homeostasis will likely have broad application and utility. This highly complex and multistep pathway for NO production and subsequent target activation provides many steps in the endogenous pathway that may be useful targets for drug development for cardiovascular disease, antimicrobial, cancer, wound healing, etc. This article will summarize known strategies that are currently available or in development for enhancing NO production or availability in the human body. Each strategy will be discussed including exogenous sources of NO, use of precursors to promote NO production and downstream pathways affected by NO production with advantages and disadvantages highlighted for each. Development of NO-based therapeutics is and will continue to be a major focus of biotech, academia as well as pharmaceutical companies. Application of safe and effective strategies will certainly transform health and disease.