OPIATE RECEPTORS IN THE RABBIT IRIS
OPIATE RECEPTORS IN THE RABBIT IRIS
复制标题
DOI：
10.1007/bf00504223
复制
发表时间：
1980-01-01
影响因子：
3.6
通讯作者：
SCAPAGNINI, U
中科院分区：
文献类型：
--
作者：
DRAGO, F;GORGONE, G;SCAPAGNINI, U
在眼内注射吗啡（10-100μg）和D-Ala2-met-脑啡肽（D-Ala-E，5-50μg）对瞳孔影响的体内研究中获得了表明兔虹膜中存在阿片受体的证据。两种阿片类药物都会引起瞳孔大小的显着剂量依赖性减小和瞳孔大小的明显波动。静脉注射在注射阿片类药物之前或之后给予纳洛酮（0.5 mg/kg）可防止缩瞳效应和瞳孔大小波动。在存在和不存在纳洛酮的情况下阿片类药物的剂量反应曲线的平行性表明竞争性可逆拮抗作用。
Evidence pointing to the presence of opiate receptors in the rabbit iris was obtained in an in vivo study of the effects on the pupil of the intraocular injection of morphine (10-100 .mu.g) and D-Ala2-met-enkephalinamide (D-Ala-E, 5-50 .mu.g). Both opiates induced a significant dose-dependent decrease in pupillary size and an appreciable fluctuation of pupillary size. I.v. naloxone administration (0.5 mg/kg) before or after injection of opiates prevented the miotic effect and the pupil size fluctuation. The parallelism of the dose-response curves of opiates in the presence and absence of naloxone indicated competitive reversible antagonism.