C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
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DOI：
10.1126/science.271.5247.348
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发表时间：
1996-01-19
期刊：
影响因子：
56.9
通讯作者：
Fearon, DT
中科院分区：
文献类型：
--
作者：
Dempsey, PW;Allison, MED;Fearon, DT
最佳的免疫反应应区分有害和无害的抗原。原始的先天免疫系统，如补体系统，可能在这种区别中发挥作用。当被激活时，补体的C3成分会附着在微生物上的潜在抗原上。为了确定这是否改变了获得性免疫识别，用融合到小鼠C3d的重组模式抗原--鸡蛋溶菌酶(HEL)免疫小鼠。携带两份和三份C3d的HEL的免疫原性分别是单独携带HEL的1000倍和10,000倍。因此，C3d是一种天然免疫的分子佐剂，它深刻地影响获得性免疫反应。
An optimal immune response should differentiate between harmful and innocuous antigens. Primitive systems of innate immunity, such as the complement system, may play a role in this distinction. When activated, the C3 component of complement attaches to potential antigens on microorganisms. To determine whether this alters acquired immune recognition, mice were immunized with a recombinant model antigen, hen egg lysozyme (HEL), fused to murine C3d. HEL bearing two and three copies of C3d was 1000- and 10,000-fold more immunogenic, respectively, than HEL alone. Thus, C3d is a molecular adjuvant of innate immunity that profoundly influences an acquired immune response.