Structural brain correlates of obstructive sleep apnoea in older adults at risk for dementia
Structural brain correlates of obstructive sleep apnoea in older adults at risk for dementia
复制标题
DOI：
10.1183/13993003.00740-2018
复制
发表时间：
2018-07-01
影响因子：
24.3
通讯作者：
Naismith, Sharon L.
中科院分区：
文献类型：
--
作者：
Cross, Nathan E.;Memarian, Negar;Naismith, Sharon L.
本研究旨在探讨阻塞性睡眠呼吸暂停（OSA）和大脑皮层厚度之间的关联，在老年人的主观和客观认知困难，谁被认为是“风险”的痴呆症。83中年到老年人（51-88岁）进行神经心理测试，多导睡眠图评估OSA和结构磁共振成像脑扫描。对OSA措施进行了主成分分析。皮质厚度和皮质下体积与提取的“氧饱和度降低”和“睡眠障碍”成分进行比较。氧饱和度降低与双侧颞叶皮质厚度降低显著相关（左：r=-0.44，p
This study aimed to investigate associations between obstructive sleep apnoea (OSA) and cortical thickness in older adults with subjective and objective cognitive difficulties, who are considered "at-risk" for dementia.83 middle-aged to older adults (51-88 years) underwent neuropsychological testing, polysomnography assessment of OSA and a structural magnetic resonance imaging brain scan. A principal components analysis was performed on OSA measures. Cortical thickness and subcortical volumes were compared to extracted components of "oxygen desaturation" and "sleep disturbance".Oxygen desaturation was significantly related to reduced cortical thickness in the bilateral temporal lobes (left: r=-0.44, p