Correcting the record of structural publications requires joint effort of the community and journal editors.

Correcting the record of structural publications requires joint effort of the community and journal editors.
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DOI:
10.1111/febs.13765
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发表时间:
2016-12
期刊:
The FEBS journal
影响因子:
--
通讯作者:
Jaskolski M
Jaskolski M
中科院分区:
其他
文献类型:
--
作者:
Rupp B;Wlodawer A;Minor W;Helliwell JR;Jaskolski M

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严重缺陷,甚至虚构的生物分子晶体结构模型,虽然罕见,仍然坚持在结构库和数据库的记录。因此,必须有效解决数据库污染和基于不正确结构模型的出版物持续存在的问题。负担不能简单地留给那些努力提出反对意见的批评者,而这些意见大多被忽视。整个结构生物学界,特别是在这方面行使重要权力的期刊编辑,必须参与建设性的对话,以免结构生物学失去其作为循证实证科学的可信度。有缺陷的晶体结构模型污染结构库提供了令人信服的例子,影响整个生物医学研究界的系统性问题,并建立了一个及时的起点,研究诚信的逾期讨论。纠正科学记录的负担不能简单地留给批评的声音,他们努力制造大多被忽视的不同意见。
Seriously flawed and even fictional models of biomolecular crystal structures, although rare, still persist in the record of structural repositories and databases. The ensuing problems of database contamination and persistence of publications based on incorrect structure models must be effectively addressed. The burden cannot be simply left to the critical voices who take the effort to contribute dissenting comments that are mostly ignored. The entire structural biology community, and particularly the journal editors who exercise significant power in this respect, must engage in a constructive dialogue lest structural biology lose its credibility as an evidence-based empirical science. Flawed crystal structure models polluting structural repositories provide convincing examples of systemic problems affecting the entire biomedical research community and establish a timely starting point for an overdue discussion of research integrity. The burden of correcting the scientific record cannot be simply left to critical voices who take the effort to craft dissenting comments that are mostly ignored.
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