Sustained photodynamic effect of single chirality-enriched single-walled carbon nanotubes
Sustained photodynamic effect of single chirality-enriched single-walled carbon nanotubes
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DOI：
10.1016/j.carbon.2020.02.002
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发表时间：
2020-05-01
期刊：
影响因子：
10.9
通讯作者：
Murakami, Tatsuya
中科院分区：
文献类型：
--
作者：
Fukuda, Ryosuke;Umeyama, Tomokazu;Murakami, Tatsuya
半导体单壁碳纳米管（s-SWNTs）由于其S-11和S-22跃迁对应的近红外（NIR）吸收而具有荧光发射以及光热和光动力学作用。在这里，我们发现一种手性s-SWNTs， (6,4)- swnts，以可持续的方式产生所有三种主要的活性氧，即单线态氧（O-1(2)），超氧阴离子（O-2中心点（-））和羟基自由基（中心点OH）。其中心点OH生成效率显著高于其他两种测试的手性s- swnt，以及临床近红外染料。（6,4）-SWNTs中这种持续且相对较高的光动力效应是由于它们具有非凡的高光稳定性和相对较高的三重态激发态生成效率。在生理条件下(6,4)-单壁碳纳米管的胶体稳定过程中，一种由两亲性选择的串联重复序列组成的血清蛋白被发现有助于分散。蛋白包被的(6,4)- swnt能够通过持续的光动力作用有效地消融癌细胞并分解淀粉样蛋白-肽聚集体。(C) 2020作者。Elsevier Ltd.出版。
Semiconducting single-walled carbon nanotubes (s-SWNTs) are capable of fluorescence emission as well as photothermal and photodynamic actions, resulting from their near-infrared (NIR) absorptions corresponding to their S-11 and S-22 transitions. Here, we show that one chiral s-SWNTs, (6,4)-SWNTs, photogenerates all three of the major reactive oxygen species, i.e., singlet oxygen (O-1(2)), superoxide anion (O-2 center dot(-)), and hydroxyl radical (center dot OH), in a sustainable manner. Its efficiency for center dot OH generation is dramatically higher than those of the other two chiral s-SWNTs tested, as well as a clinical NIR dye. This sustained and relatively high photodynamic effect in (6,4)-SWNTs is due to their extraordinary high photostability and relatively high generation efficiency of their triplet excited state. In the colloidal stabilization of (6,4)-SWNTs under physiological conditions, a serum protein consisting of a tandem repeat of amphiphilic cchelices is found to be useful for dispersion. The protein-coated (6,4)-SWNTs are capable of effectively ablating cancer cells and disintegrating amyloid beta peptide aggregates through sustained photodynamic action. (C) 2020 The Authors. Published by Elsevier Ltd.