Congenital myotonia in related kittens
Congenital myotonia in related kittens
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DOI：
10.1111/j.1748-5827.1998.tb03651.x
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发表时间：
1998-06-01
影响因子：
1.6
通讯作者：
Alley, MR
中科院分区：
文献类型：
--
作者：
Hickford, FH;Jones, BR;Alley, MR
四只密切相关的家养短毛小猫在被发现步态异常、张嘴困难和肌肉肥大后接受了调查。他们走路时步态僵硬、不自然，运动时僵硬会减少。小猫受到惊吓会导致四肢过度伸展并侧卧，或眼轮匝肌痉挛、瞬膜长时间脱垂和耳朵变平。一只小猫间歇性发声困难。麻醉小猫的气管插管很困难，因为它们无法张大嘴，并且肌肉痉挛导致声门变窄。先天性肌强直的诊断是根据临床症状、小猫的年龄、肌电图上典型的肌强直放电以及肌肉的组织病理学和组织化学结果做出的。这是该物种先天性肌强直的首次报道。
Four closely related domestic shorthair kittens were investigated following the detection of abnormalities in their gait, difficulty opening their mouths and muscle hypertrophy. They walked with a stiff, stilted gait, with the stiffness reducing during exercise. Startling of the kittens resulted in hyperextension of the limbs and falling to lateral recumbency, or spasm of the orbicularis oculi muscle, prolonged prolapse of the nictitating membranes and flattening of the ears. One kitten was intermittently dysphonic. Endotracheal intubation of the anaesthetised kittens was difficult due to an inability to open the mouth to a wide angle, and narrowing of the glottis due to muscle spasm. A diagnosis of congenital myotonia was made based on the clinical signs, the kittens' ages, typical myotonic discharges on electromyography, and the histopathological and histochemical findings in muscle. This is the first report of congenital myotonia in this species.