Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis
Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis
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DOI：
10.1111/acps.12336
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发表时间：
2014-12-01
影响因子：
6.7
通讯作者：
Stubbs, B.
中科院分区：
文献类型：
--
作者：
Mitchell, A. J.;Beaumont, H.;Stubbs, B.
目的调查是否有主观记忆投诉（SMC），但没有客观缺陷的人发展为轻度认知障碍（MCI）和痴呆的风险增加。方法主要的电子数据库检索至2014年3月，并使用初始队列研究进行荟萃分析。结果在28项研究中，有29723名独特的个体（14714名患有SMC，15009名没有SMC）（平均71.6年），平均随访4.8年直至痴呆。与无SMC的患者（n=15009）相比，SMC向痴呆的年转化率（ACR）为2.33%（95%CI =1.93%-2.78%），相对风险（RR）为2.07（95%CI =1.76-2.44）。11项研究中发生MCI的ACR为6.67%（95%CI =4.70-8.95%）。在超过40年的长期研究中，14.1%（9.67-19.1%）的SMC患者发展为痴呆，26.6%（95%CI =5.3-39.7）的患者发展为MCI。ACR从SMC到痴呆症和MCI在社区和非社区settings.Conclusionolder人与SMC，但没有客观的投诉是两倍的可能性发展为痴呆症的个人没有SMC。每年约有2.3%和6.6%的老年SMC患者将进展为痴呆和MCI。
ObjectiveTo investigate whether people with subjective memory complaints (SMC) but no objective deficits are at increased risk of developing mild cognitive impairment (MCI) and dementia.MethodMajor electronic databases were searched till 03/2014, and a meta-analysis was conducted using inception cohort studies.ResultsAcross 28 studies, there were 29723 unique individuals (14714 with SMC and 15009 without SMC) (mean 71.6years) followed on average for 4.8years through to dementia. The annual conversion rate (ACR) of SMC to dementia was 2.33% (95% CI=1.93%-2.78%) a relative risk (RR) of 2.07 (95% CI=1.76-2.44) compared with those without SMC (n=15009). From 11 studies the ACR of developing MCI was 6.67% (95% CI=4.70-8.95%). In long-term studies over 4years, 14.1% (9.67-19.1%) of people with SMC developed dementia and 26.6% (95% CI=5.3-39.7) went on to develop MCI. The ACR from SMC to dementia and MCI were comparable in community and non-community settings.ConclusionOlder people with SMC but no objective complaints are twice as likely to develop dementia as individuals without SMC. Approximately 2.3% and 6.6% of older people with SMC will progress to dementia and MCI per year.