Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women
Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women
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DOI：
10.1093/gerona/57.12.m772
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发表时间：
2002-12-01
影响因子：
5.1
通讯作者：
Kenny, AM
中科院分区：
文献类型：
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作者：
Iannuzzi-Sucich, M;Prestwood, KM;Kenny, AM
背景肌肉减少症是指骨骼肌质量随着年龄的增长而减少。本研究的目的是确定老年人，社区居住的研究志愿者人群中肌肉减少症的患病率。采用双能X线吸收法测量了195名年龄在64岁至93岁之间的女性和142名年龄在64岁至92岁之间的男性的肩胛骨骨骼肌质量。我们将少肌症定义为骨骼肌质量/身高（2）（平方米）低于年轻健康参考人群平均值的2个标准差。我们使用了两个不同的参考人群，并将我们人群中的患病率与以前研究中报道的患病率进行了比较。计算身体质量指数（BMI），并使用老年人身体活动量表、短期身体表现组合和身体表现测试来测量身体活动和表现。我们使用SF-36一般健康调查测量健康相关的生活质量。血清雌酮，雌二醇，性激素结合球蛋白，甲状旁腺激素，25-羟基维生素D在所有参与者进行了测量和生物可利用的睾酮只在男性进行了测量。对男性进行腿部推举力量和腿部推举功率的测定。在我们的队列中，肌肉减少症的患病率在女性中为22.6%，在男性中为26.8%。对80岁或80岁以上的女性和男性进行的亚组分析显示，患病率分别为31.0%和52.9%。在女性中，骨骼肌质量与BMI和血清雌酮、雌二醇和25-羟基维生素D水平显著相关;在男性中，它与BMI、单腿站立时间、腿部按压力量、腿部按压功率、SF-36一般健康评分、体能测试总分和生物可利用睾酮水平显著相关。使用线性回归分析，BMI是女性骨骼肌质量的唯一预测因子，占方差的47.9%（p <0.05）。在男性中，BMI占50.1%，平均力量占10.3%，平均功率占4.1%，生物可利用的睾酮占2.6%的非骨骼肌质量的方差（p <0.05）。肌肉减少症常见于65岁以上的成年人，并随年龄增长而增加。BMI是女性和男性骨骼肌质量的强有力预测因素。力量，权力和生物可利用的睾酮是男性的进一步贡献者。这些数据表明，应进一步研究针对营养，力量训练和睾酮替代疗法的干预措施在预防随年龄增长的肌肉损失中的作用。
Background. Sarcopenia refers to the loss of skeletal muscle mass with age. The objective of this study was to determine the prevalence of sarcopenia in a population of older, community-dwelling research volunteers.Methods. Appendicular skeletal muscle mass was measured by dual x-ray absorptiometry in 195 women aged 64 to 93 years and 142 men aged 64 to 92 years. We defined sarcopenia as appendicular skeletal muscle mass/height(2) (square meters) less than 2 standard deviations below the mean for young, healthy reference populations. We used two different reference populations and compared prevalence in our population to that reported in previous studies. Body mass index (BMI) was calculated and physical activity and performance were measured with the Physical Activity Scale for the Elderly, the Short Physical Performance Battery, and the Physical Performance Test. We measured health-related quality of life by using the SF-36 general health survey. Serum estrone, estradiol, sex hormone-binding globulin, parathyroid hormone, and 25-hydroxy vitamin D were measured in all participants and bioavailable testosterone was measured only in men. Leg press strength and leg press power were determined in men.Results. The prevalence of sarcopenia in our cohort was 22.6% in women and 26.8% in men. A subgroup analysis of women and men 80 years or older revealed prevalence rates of 31.0% and 52.9%, respectively. In women, skeletal muscle mass correlated significantly with BMI and levels of serum estrone, estradiol, and 25-hydroxy vitamin D; in men, it correlated significantly with BMI, single leg stance time, leg press strength, leg press power, SF-36 general health score, Physical Performance Test total score, and bioavailable testosterone levels. With the use of linear regression analysis, BMI was the only predictor of appendicular skeletal muscle mass in women, accounting for 47.9% of the variance (p < .05). In men, BMI accounted for 50.1%, mean strength accounted for 10.3%, mean power accounted for 4.1%, and bioavailable testosterone accounted for 2.6% of the variance in appendicular skeletal muscle mass (p < .05).Conclusions. Sarcopenia is common in adults over the age of 65 years and increases with age. BMI is a strong predictor of skeletal muscle mass in women and men. Strength, power, and bioavailable testosterone are further contributors in men. These data suggest that interventions to target nutrition, strength training, and testosterone replacement therapy should be further investigated for their role in preventing muscle loss with age.