Rhodium-Catalyzed Double Isocyanide Insertion via a Vinylcarbodiimide Intermediate for the Synthesis of 2 H -Pyrrol-2-imines
Rhodium-Catalyzed Double Isocyanide Insertion via a Vinylcarbodiimide Intermediate for the Synthesis of 2 H -Pyrrol-2-imines
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通过乙烯基碳二亚胺中间体进行铑催化双异氰化物插入合成 2 H-吡咯-2-亚胺
DOI：
10.1055/s-0037-1611830
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Zhang Zhenhua
中科院分区：
文献类型：
--
作者：
Wang Yunlong;Li Zongyang;Zhao Haiying;Zhang Zhenhua
2 H-吡咯-2-亚胺（2 H-Pyrrol-2-imine）是生物活性化合物和天然产物的重要结构基序。报道了一种铑催化的叠氮乙烯基与两种异腈的一锅法反应，该反应提供了一种简便的合成3-氨基-5-芳基-2H-吡咯-2-亚胺的方法，并以较好的产率合成了3-氨基-5-芳基-2H-吡咯-2-亚胺。不稳定的乙烯基碳二亚胺是该级联反应中的关键中间体。
2H-Pyrrol-2-imine is an important structural motif exhibiting in biologically active compounds and natural products. An efficient rhodium-catalyzed one-pot reaction of one vinyl azide with sequentially with two different isocyanides is reported, which offers an alternative facile access to 3-amino-5-aryl-2H-pyrrol-2-imines bearing various substitution on the nitrogens in good yields. An unstable vinylcarbodiimide is the key intermediate in this cascade reaction.