Dose-intensive approaches to ovarian cancer.
Dose-intensive approaches to ovarian cancer.
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DOI：
10.1007/s11912-999-0010-x
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发表时间：
1999-09-01
影响因子：
4.7
通讯作者：
Trimble, E L
中科院分区：
文献类型：
--
作者：
Lambrou, N;Trimble, E L
增加铂的总剂量或剂量强度并不能改善卵巢癌女性的生存率。尚未证明高剂量化疗联合血液支持比标准剂量化疗更有效。通过腹腔化疗进行区域剂量强度可能在晚期卵巢癌的治疗中发挥作用。除了铂和紫杉烷之外，还需要进一步的研究来确定用于卵巢癌初级治疗的最佳药物组合。
Increasing the total dose or the dose intensity of platinum does not improve survival in women with ovarian cancer. High-dose chemotherapy with hematologic support has not been shown to be more effective than standard-dose chemotherapy. Regional dose intensity, through intraperitoneal chemotherapy, may have a role in the treatment of advanced ovarian cancer. Further studies are needed to identify the optimal combination of agents, in addition to a platinum and a taxane, to be used in primary therapy for ovarian cancer.