Prospective study of factors influencing the onset of natural menopause
Prospective study of factors influencing the onset of natural menopause
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DOI：
10.1016/s0895-4356(98)00119-x
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发表时间：
1998-12-01
影响因子：
7.2
通讯作者：
Zeleniuch-Jacquotte, A
中科院分区：
文献类型：
--
作者：
Kato, I;Toniolo, P;Zeleniuch-Jacquotte, A
更年期过晚或过早都与女性患上几种慢性病的风险有关。为了研究影响自然绝经开始的因素，作者分析了参加纽约大学女性研究的4694名绝经前女性的随访数据，年龄在34-61岁之间。在平均5.4年的观察中，有2035例发生更年期，中位年龄为51.3岁。目前吸烟者经历更年期的时间比从不吸烟者早0.75年。那些每天吸烟超过10支的人患更年期提前的风险增加了40%。相比之下，有三个或三个以上孩子的女性经历更年期的时间比未分娩的女性晚0.86年，比天主教女性晚0.66年。随着体重指数的增加，更年期年龄也略有增加。这项前瞻性研究提供了可靠的流行病学证据，表明吸烟以外的其他几个因素对自然更年期的开始也有影响。《CLIN流行病学杂志》51；12：1271-1276,1998。(C)1998年爱思唯尔科学公司。
Late or early menopause has been implicated in risk of several chronic diseases in women. To study factors influencing the onset of natural menopause, the authors analyzed the follow-up data of 4694 premenopausal women who enrolled in the New York University Women Study at ages 34-61. In an average of 5.4 years of observation, there were 2035 incidences of menopause, with the median age of 51.3 years. Current smokers experienced menopause 0.75 years earlier than never-smokers. Those who smoked more than 10 cigarettes per day had a 40% increase in risk of earlier menopause. In contrast, women who had three or more children experienced menopause 0.86 years later than nulliparous women, and Jewish women, 0.66 years later than Catholic women. There was also a modest increase in the age at menopause with increasing body mass index. This prospective study provides solid epidemiologic evidence that several factors other than cigarette smoking have impact on the onset of natural menopause. J CLIN EPIDEMIOL 51;12:1271-1276, 1998. (C) 1998 Elsevier Science Inc.