Lasting influence of repetitive transcranial magnetic stimulation on intracortical excitability in human subjects
Lasting influence of repetitive transcranial magnetic stimulation on intracortical excitability in human subjects
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DOI：
10.1016/s0304-3940(00)01132-0
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发表时间：
2000-06-16
影响因子：
2.5
通讯作者：
Paulus, W
中科院分区：
文献类型：
--
作者：
Wu, T;Sommer, M;Paulus, W
我们研究了30个脉冲的重复经颅磁刺激(RTMS)对人类运动皮质兴奋性的影响，其频率分别为5和15 Hz，强度为静息运动阈值的120%。采用条件性实验设计的双脉冲范式，检测rTMS后皮层内抑制(ICI)和皮层内促进(ICF)。15 HzrTMS后，ICI显著降低3.2min，ICF增强1.5min，单次TMS的肌肉诱发电位仅在前30天显著增加。在5 HzrTMS后，前32个S的ICI明显降低。我们认为高频阈值上rTMS可一过性抑制皮层内抑制回路的活动，并以不同的时间进程增加兴奋回路的兴奋性。(C)2000爱思唯尔爱尔兰科学有限公司。保留所有权利。
We studied the effects of a train of 30 pulses of repetitive transcranial magnetic stimulation (rTMS) at frequencies of 5 and 15 Hz and at an intensity of 120% of resting motor threshold on human motor cortex excitability. Intracortical inhibition (ICI) and intracortical facilitation (ICF) after rTMS were tested by a conditioning-test designed paired-pulse paradigm. After 15 Hz rTMS, ICI was significantly reduced for 3.2 min, ICF was enhanced for 1.5 min, muscle evoked potentials from single TMS were increased in the first 30 s only. After 5 Hz rTMS ICI was significantly reduced in the first 32 s. We conclude that high-frequency suprathreshold rTMS transiently suppresses the activity of the intracortical inhibitory circuitry and, with a different time course, increases the excitability of the excitatory circuitry. (C) 2000 Elsevier Science ireland Ltd. All rights reserved.