Catalyst-and solvent-free, pot, atom and step economic synthesis of tetrahydroquinazolines by an aza-Diels-Alder reaction strategy
Catalyst-and solvent-free, pot, atom and step economic synthesis of tetrahydroquinazolines by an aza-Diels-Alder reaction strategy
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DOI：
10.1039/c3gc42389a
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发表时间：
2014-01-01
期刊：
影响因子：
9.8
通讯作者：
Prajapati, Dipak
中科院分区：
文献类型：
--
作者：
Bhuyan, Debajyoti;Sarma, Rupam;Prajapati, Dipak
采用微波辅助无溶剂、无催化剂的四组分aza-Diels-Alder反应策略，实现了锅原子步经济（PASE）合成四氢喹唑啉。该方法的关键步骤是二烯和亲二烯试剂的原位生成以及它们随后的反应以得到所需的产物。
A pot, atom and step economic (PASE) synthesis of tetrahydroquinazolines has been achieved via a microwave-assisted four-component catalyst- and solvent-free aza-Diels-Alder reaction strategy. The key step of the methodology is the in situ generation of both the diene and the dienophile and their subsequent reaction to give the desired product.