Vertebrate Chromosome Evolution
Vertebrate Chromosome Evolution
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DOI：
10.1146/annurev-animal-020518-114924
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发表时间：
2021-01-01
期刊：
影响因子：
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通讯作者：
Lewin, Harris A.
中科院分区：
文献类型：
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作者：
Damas, Joana;Corbo, Marco;Lewin, Harris A.
由于DNA测序技术的进步促进了染色体规模的全基因组从头组装的产生，染色体进化的研究正在重新引起人们的兴趣。这篇综述着重于该领域的历史、方法、发现和当前面临的挑战，重点是脊椎动物基因组。详细检查染色体重排的生物学文献，特别是染色体重排和表型进化，适应和物种形成之间的关系。一个关键的审查方法，用于识别，表征和可视化染色体重排和计算重建祖先核型。最后，我们展望未来，确定了数百乃至数千个染色体规模组装体的积累所带来的巨大技术和科学挑战。
The study of chromosome evolution is undergoing a resurgence of interest owing to advances in DNA sequencing technology that facilitate the production of chromosome-scale whole-genome assemblies de novo. This review focuses on the history, methods, discoveries, and current challenges facing the field, with an emphasis on vertebrate genomes. A detailed examination of the literature on the biology of chromosome rearrangements is presented, specifically the relationship between chromosome rearrangements and phenotypic evolution, adaptation, and speciation. A critical review of the methods for identifying, characterizing, and visualizing chromosome rearrangements and computationally reconstructing ancestral karyotypes is presented. We conclude by looking to the future, identifying the enormous technical and scientific challenges presented by the accumulation of hundreds and eventually thousands of chromosome-scale assemblies.