Role of autophagy in the regulation of epithelial cell junctions.
Role of autophagy in the regulation of epithelial cell junctions.
复制标题
自噬在上皮细胞连接调节中的作用。
DOI：
10.1080/21688370.2016.1171284
复制
发表时间：
2016
期刊：
影响因子：
3.1
通讯作者：
Ma,Thomas
中科院分区：
文献类型：
--
作者：
Nighot,Prashant;Ma,Thomas
自噬是一种细胞存活机制，通过该机制，大量细胞质物质，包括可溶性大分子和细胞器，被靶向用于溶酶体降解。自噬在代谢应激、神经变性、癌症、衰老、免疫和炎性疾病等多种细胞过程中的作用正日益被认识。上皮细胞连接通过物理结合、调节细胞旁通路、将细胞外信号整合到细胞内信号传导中以及细胞-细胞通信在细胞稳态中发挥不可或缺的作用。最近的数据表明，细胞连接组成是非常动态的。连接蛋白复合物通过细胞内运输和降解途径对各种细胞内和细胞外线索进行主动调节。本文综述了自噬如何调节各种上皮细胞连接的最新和新兴的信息。上皮连接的自噬调节的知识将为在各种人类疾病条件下靶向自噬提供进一步的理论基础。
Autophagy is a cell survival mechanism by which bulk cytoplasmic material, including soluble macromolecules and organelles, is targeted for lysosomal degradation. The role of autophagy in diverse cellular processes such as metabolic stress, neurodegeneration, cancer, aging, immunity, and inflammatory diseases is being increasingly recognized. Epithelial cell junctions play an integral role in the cell homeostasis via physical binding, regulating paracellular pathways, integrating extracellular cues into intracellular signaling, and cell-cell communication. Recent data indicates that cell junction composition is very dynamic. The junctional protein complexes are actively regulated in response to various intra- and extra-cellular clues by intracellular trafficking and degradation pathways. This review discusses the recent and emerging information on how autophagy regulates various epithelial cell junctions. The knowledge of autophagy regulation of epithelial junctions will provide further rationale for targeting autophagy in a wide variety of human disease conditions.