Ventilatory response of the cat to hypoxia in sleep and wakefulness
Ventilatory response of the cat to hypoxia in sleep and wakefulness
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DOI：
10.1152/japplphysiol.01051.2002
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发表时间：
2003-08-01
影响因子：
3.3
通讯作者：
Orem, JM
中科院分区：
文献类型：
--
作者：
Lovering, AT;Dunin-Barkowski, WL;Orem, JM
本研究的特点是通风，气流波形，并在睡眠和觉醒期间的完整的成年猫缺氧反应mammatic活动。暴露于缺氧长达3小时引起持续过度通气在清醒和睡眠。换气过度是由于潮气量和频率增加导致每分钟通气量显著增加。横膈膜活动发生显着变化，从常氧下吸气后吸气活动（PIIA）较小的活动增强到缺氧下吸气后吸气活动（PIIA）增加的活动增强。PIIA的增加在快速眼动睡眠中最少。呼吸活动的这些变化与吸气和呼气时气流波形的变化有关。我们的结论是，对缺氧的解释性反应涉及中央模式发生器输出的变化，这种变化部分取决于意识状态。
This study characterized ventilation, the airflow waveform, and diaphragmatic activity in response to hypoxia in the intact adult cat during sleep and wakefulness. Exposure to hypoxia for up to 3 h caused sustained hyperventilation during both wakefulness and sleep. Hyperventilation resulted from significant increases in minute ventilation due to increases in both tidal volume and frequency. Diaphragmatic activity changed significantly from augmenting activity with little postinspiratory-inspiratory activity ( PIIA) in normoxia to augmenting activity with increased PIIA in hypoxia. The increase in PIIA was least in rapid eye movement sleep. These changes in diaphragmatic activity were associated with changes in airflow waveforms in inspiration and expiration. We conclude that the ventilatory response to hypoxia involves a change in the output of the central pattern generator and that the change is dependent in part on the state of consciousness.