FECAL BILE-ACID CONCENTRATIONS OF PATIENTS WITH CARCINOMA OR INCREASED RISK OF CARCINOMA IN THE LARGE BOWEL
FECAL BILE-ACID CONCENTRATIONS OF PATIENTS WITH CARCINOMA OR INCREASED RISK OF CARCINOMA IN THE LARGE BOWEL
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作者：
MUDD, DG;MCKELVEY, STD;ROY, AD
粪便中的3-羟基胆汁酸进行了测定酶在癌症患者，或在发展大肠癌的风险增加。在溃疡性结肠炎、既往切除腺瘤或切除癌的患者中，胆汁酸浓度没有升高。治疗前，癌症患者的粪便胆汁酸浓度与对照值相似，手术并不影响平均水平。这些发现质疑粪便中3-羟基胆汁酸浓度在大肠癌发病机制中的重要性。
Faecal 3-hydroxy bile acids were assayed enzymatically in patients with carcinoma, or at increased risk of developing carcinoma of the large bowel. No rise in bile acid concentration was demonstrated in patients with ulcerative colitis, previously resected adenoma, or resected carcinoma. Patients with carcinoma, before treatment, had faecal bile acid concentrations similar to control values, and surgery did not affect the mean level. These findings cast doubt on the importance of the 3-hydroxy bile acid concentration in the faeces in the pathogenesis of large bowel cancer.