Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains
Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains
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DOI：
10.1016/s0955-0674(97)80030-0
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发表时间：
1997-08-01
影响因子：
7.5
通讯作者：
Simons, K
中科院分区：
文献类型：
--
作者：
Harder, T;Simons, K
越来越多的证据表明，鞘脂和胆固醇的侧向组装（筏）形成平台，用于支持膜运输和信号转导中的许多细胞事件。筏膜微区被认为通过优先与特定蛋白质结合而排除其他蛋白质来发挥作用。驱动筏形成的基本力是脂质相互作用，其本身是弱的和短暂的。因此，鞘脂筏应被认为是动态结构，其中胆固醇起着重要的作用，作为一个连接器。窖蛋白通过在细胞内膜和质膜上形成稳定的筏结构域来影响这些动力学。最近的数据表明，集群筏组件可以调节筏动力学，因此代表了这些膜微区的功能中的一个重要特征。
There is accumulating evidence that lateral assemblies (rafts) of sphingolipids and cholesterol form platforms that serve to support numerous cellular events in membrane traffic and signal transduction. Raft membrane microdomains are thought to function by preferentially associating with specific proteins while excluding others, The basic forces driving raft formation are lipid interactions which are, per se, weak and transient. Sphingolipid rafts should therefore be considered to be dynamic structures in which cholesterol plays an important role as a linker. Caveolins influence these dynamics by forming stabilized raft domains in intracellular membranes as well as at the plasma membrane. Recent data suggest that clustering of raft components could regulate raft dynamics and therefore represents an important feature in the function of these membrane microdomains.