Chemotherapeutic malaria control operation by single dose of Fansidar plus primaquine in North Sumatra, Indonesia.
Chemotherapeutic malaria control operation by single dose of Fansidar plus primaquine in North Sumatra, Indonesia.
复制标题
印度尼西亚北苏门答腊岛通过单剂 Fansidar 加伯氨喹进行的化疗疟疾控制手术。
DOI：
--
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
A. Ishii
中科院分区：
文献类型：
--
作者：
H. Doi;A. Kaneko;W. Panjaitan;A. Ishii
1987/1988年在印度尼西亚北苏门答腊岛的东海岸村庄进行了选择性年龄分组治疗和村级规模的疟疾化疗控制行动。在配子体阶段采用单剂范西达加伯喹作为药物方案，以切断疟疾的传播。治疗后第7天，72例恶性疟原虫配子体携带者配子体阳性率降至2.7%。在小学连续进行选择性年龄组治疗后，社区恶性疟患病率显著下降，但间日疟流行仍在持续。由1名卫生院工作人员和2名村卫生志愿者开展村级活动性病例发现工作。8个月后，恶性疟原虫流行率从14%降至1%。由于在沿海地区高发村庄开展了化疗控制活动，与1985/1986年相比，1988年的疟疾流行率变得非常低。
Selective age group treatment and village scale chemotherapeutic malaria control operation were carried out in east-coast villages in North Sumatra, Indonesia in 1987/1988. A single dose of Fansidar plus primaquine was adopted as the drug regimen to cut the transmission of malaria at the gametocyte stage. After the treatment on day seven, the gametocyte positive rate was reduced to only 2.7% in 72 Plasmodium falciparum gametocyte carriers. A significant reduction of P. falciparum prevalence in the community was observed after successive selective age group treatment in primary school, however P. vivax prevalence persisted. Village scale active case detection was carried out by one health center staff and two village health volunteers. After eight months P. falciparum prevalence was reduced from 14% to 1%. As the result of the chemotherapeutic control activities covering high-prevalence villages in the coastal area, malaria prevalence in 1988 became very low, as compared with the status in 1985/1986.