Effects of atorvastatin loading prior to primary percutaneous coronary intervention on endothelial function and inflammatory factors in patients with ST-segment elevation myocardial infarction.
Effects of atorvastatin loading prior to primary percutaneous coronary intervention on endothelial function and inflammatory factors in patients with ST-segment elevation myocardial infarction.
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DOI：
10.3892/etm.2013.1432
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发表时间：
2014-02
影响因子：
2.7
通讯作者：
Cui M
中科院分区：
文献类型：
--
作者：
Yong H;Wang X;Mi L;Guo L;Gao W;Zhang Y;Cui M
先前的研究已经证明了他汀类药物在择期和早期经皮冠状动脉介入治疗（PCI）之前负荷的有益作用，其中他汀类药物的“多效性”可能有助于这些临床益处。本研究的目的是探讨直接 PCI 前阿托伐他汀负荷对急性 ST 段抬高型心肌梗死 (STEMI) 患者冠状动脉内皮功能和炎症因子的潜在影响。总共 60 名 STEMI 患者被随机分为三组：负荷剂量组（PCI 前 80 mg 阿托伐他汀；n=20）、常规剂量组（PCI 前 20 mg 阿托伐他汀；n=20）和对照组（PCI 前未服用阿托伐他汀；n=20）。所有患者在 PCI 前、PCI 后立即、6 小时和 24 小时收集血浆样本。使用ELISA检测内皮一氧化氮合酶（eNOS）、一氧化氮（NO）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和细胞间粘附分子-1（ICAM-1）的血浆浓度。常规剂量组PCI术后即刻和24小时血浆eNOS水平显着高于其他组。然而，三组在PCI前和PCI后6小时的血浆eNOS浓度或任何时间点的血浆NO浓度均无显着差异。负荷剂量组PCI前血浆IL-6水平显着低于其他组；然而，三组间任何时间点 PCI 后血浆 IL-6 浓度或 TNF-α 和 ICAM-1 浓度均无显着差异。总之，接受直接 PCI 的 STEMI 患者阿托伐他汀负荷可能对内皮功能和炎症反应没有保护作用。
Previous studies have demonstrated the beneficial effect of statin loading prior to elective and early percutaneous coronary intervention (PCI), in which the ‘pleiotropic effects’ of statins may contribute to these clinical benefits. The aim of the present study was to examine the potential effects of atorvastatin loading prior to primary PCI on coronary endothelial function and inflammatory factors in patients with acute ST-segment elevation myocardial infarction (STEMI). A total of 60 patients with STEMI were randomized into three groups: Loading dose (80 mg atorvastatin prior to PCI; n=20), regular dose (20 mg atorvastatin prior to PCI; n=20) and control (without atorvastatin prior to PCI; n=20). The plasma samples were collected prior to, and immediately, 6 and 24 h after PCI in all the patients. The plasma concentrations of endothelial nitric oxide synthase (eNOS), nitric oxide (NO), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1) were examined using ELISA. The plasma eNOS levels immediately and 24 h after PCI were significantly higher in the regular dose group compared with the other groups. However, there were no significant differences in the plasma eNOS concentration prior to and 6 h after PCI, or in the plasma NO concentration at any of the time-points among the three groups. The plasma IL-6 levels prior to PCI were significantly lower in the loading dose group compared with the other groups; however, there were no significant differences in the plasma concentration of IL-6 following PCI or in the concentrations of TNF-α and ICAM-1 at any of the time-points among the three groups. In conclusion, atorvastatin loading in patients with STEMI undergoing primary PCI may not have protective effects on endothelial function and the inflammatory reaction.
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影响因子：
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通讯作者：
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