Management of acute myocardial infarction: evaluating the past, practicing in the present, elaborating the future.
Management of acute myocardial infarction: evaluating the past, practicing in the present, elaborating the future.
复制标题
急性心肌梗死的治疗：回顾过去，实践现在，阐述未来。
DOI：
10.1016/s0002-8703(96)90337-3
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发表时间：
1996
影响因子：
4.8
通讯作者：
G. Steurer
中科院分区：
文献类型：
--
作者：
D. Glogar;P. Yang;G. Steurer
急性心肌梗死的管理最初集中在治疗和/或预防并发症。在溶栓前时期，治疗方案主要包括抗心绞痛和抗血栓药物的使用。半侵入性血流动力学引导治疗概念的发展导致临床结局的显著改善。在引入“波前现象”后，开发了多种药物治疗策略，目标是缩小梗死面积。溶栓药物的使用可缩小急性心肌梗死患者的梗死面积，改善预后。在专门的中心进行了急性血管成形术干预，以实现快速恢复冠状动脉血流。然而，保护心肌免受再灌注损伤仍然是一个悬而未决的问题。因此，静脉注射镁结合新的和更好的再通技术可能是急性心肌梗死患者的一种有前途的治疗策略。
The management of acute myocardial infarction initially focused on treatment and/or prevention of complications. In the prethrombolytic era, therapeutic regimens mainly comprised the use of antianginal and antiarrhythmic drugs. The development of semi-invasive hemodynamically guided treatment concepts led to remarkable improvement in clinical outcome. After the introduction of the “wave-front phenomenon,” multiple pharmacologic treatment strategies were developed with the goal of infarct size reduction. The use of thrombolytic agents reduced infarct size and improved prognosis of patients with acute myocardial infarction. Acute angioplastic intervention was introduced in specialized centers to achieve rapid restoration of coronary blood flow. The protection of the myocardium from reperfusion injury, however, remains an unresolved issue. Intravenous magnesium administration in conjunction with new and better recanalization techniques could therefore be a promising therapy strategy in patients with acute myocardial infarction.
影响因子：
158.5
作者：
PFEFFER, MA;LAMAS, GA;BRAUNWALD, E
通讯作者：
BRAUNWALD, E