Risk factors for steroid response among cataract patients
Risk factors for steroid response among cataract patients
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DOI：
10.1016/j.jcrs.2010.10.051
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发表时间：
2011-04-01
影响因子：
2.8
通讯作者：
Tripodis, Yorghos
中科院分区：
文献类型：
--
作者：
Chang, David F.;Tan, Jeffrey J.;Tripodis, Yorghos
PURPOSE: To evaluate the age and ocular axial length (AL) of topical steroid responders after uneventful cataract surgery.SETTING: Private practice, Los Altos, California, USA.DESIGN: Case-control study.METHODS: This retrospective chart review comprised consecutive patients from a single-surgeon practice who had cataract surgery during a 2-year period. All patients routinely received topical prednisolone acetate 1.0% postoperatively. In addition to AL and patient age, the intraocular pressure (IOP) was recorded preoperatively, 1 day postoperatively, and at least 1 additional time in the first postoperative month while the patient was taking a topical corticosteroid agent. A steroid response was defined as an IOP increase greater than 25% while on topical prednisolone (minimum 28 mm Hg) followed by a decrease of more than 25% after topical prednisolone was discontinued. The age and AL were compared between steroid responders with nonresponders.RESULTS: Of the 1642 patients, 39 were diagnosed as steroid responders. Younger age and a longer AL were associated with a higher risk for steroid response, particularly in patients younger than 65 years with an AL of at least 29.0 mm. These patients had a 39-fold increased risk for an IOP higher than 28 mm Hg and a 35-fold increased risk for an IOP higher than 35 mm Hg than patients older than 65 years with a normal AL.CONCLUSION: Younger patients with high myopia had a higher risk for a postoperative steroid response after uneventful cataract surgery and may require more frequent IOP monitoring or alternative topical antiinflammatory medications.
