Change of antigenic expression on rat tumor cells after their transplantation.
Change of antigenic expression on rat tumor cells after their transplantation.
复制标题
大鼠肿瘤细胞移植后抗原表达的变化。
DOI：
10.1093/jnci/55.5.1079
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发表时间：
1975
期刊：
影响因子：
--
通讯作者：
T. Kawamura
中科院分区：
文献类型：
--
作者：
E. Gotohda;F. Sendo;M. Nakayama;M. Hosokawa;T. Kawamura
Antigenic expression of 3-methylcholanthrene-induced transplantable fibrosarcoma KMT-17 cells was investigated in relation to days after ip transplantation. Cytotoxicity tests with antiserum against tumor-associated surface antigen of KMT-17 cells revealed that cytotoxic sensitivity and absorbing capacity decreased after transplantation, but they increased when other normal rats were given transplants of tumor cells. A decrease in the sensitivity was observed when immunosuppressively irradiated rats were given tumor transplants. Tumor cell density in the abdominal cavities of rats directly and absorbing capacity of KMT-17 cells to antiserum against the histocompatibility antigen did not change after transplantation. The possible mechanisms of antigenic change of KMT-17 cells were discussed.
