Association of intrauterine exposure to aspirin and blood pressure at 7 years of age: a secondary analysis
Association of intrauterine exposure to aspirin and blood pressure at 7 years of age: a secondary analysis
复制标题
宫内阿司匹林暴露与 7 岁时血压的关联：二次分析
DOI：
10.1111/1471-0528.15561
复制
发表时间：
2019-04-01
影响因子：
5.8
通讯作者：
Zhang, Y.
中科院分区：
文献类型：
--
作者：
Chen, Y.;Zhao, D.;Zhang, Y.
目的探讨母亲孕期服用阿司匹林是否与儿童期血压相关。设计/设置围产期合作项目，一项前瞻性队列研究，包括12个美国学术医疗中心之间的1959年和1976年的二次分析。有详细用药信息的妇女中的单胎生育。方法采用线性和多因素Logistic回归分析，评估母亲服用阿司匹林与儿童7岁时血压的关系。主要结果测量7岁时后代的血压。结果15 793名妇女在末次月经前4周或妊娠期服用阿司匹林。子宫内阿司匹林暴露可能与7岁时高收缩压（SBP）和舒张压（DBP）风险降低11%（95% CI 0.85- 0.93）和20%（95% CI 0.76-0.84）相关，7岁时SBP平均降低0.62 mmHg，DBP平均降低1.04 mmHg。与未接触阿司匹林的母亲所生的孩子相比，母亲在怀孕期间接触阿司匹林至少7天的孩子的高SBP和DBP风险分别降低约10%和27%，7岁时SBP和DBP平均降低0.61和1.27 mmHg。怀孕期间越早接触阿司匹林，儿童患高血压的风险就越低。结论子宫内阿司匹林暴露可能对儿童血压有长期益处。
Objective To examine whether maternal aspirin use during pregnancy is associated with childhood blood pressure. Design/Setting A secondary analysis of the Collaborative Perinatal Project, a prospective cohort study including 12 US academic medical centres between 1959 and 1976. Population Singleton births among women with detailed medication information. Methods We carried out linear and multivariate logistic regression analysis to assess the associations between maternal aspirin exposure and childhood blood pressure at age 7 years. Main outcome measures Offspring blood pressure at age 7 years. Results A total of 15 793 women were exposed to aspirin 4 weeks before the last menstrual period or during pregnancy. In utero aspirin exposure may be associated with an 11% (95% CI 0.85- 0.93) and a 20% (95% CI 0.76-0.84) reduced risk of having high systolic blood pressure (SBP) and diastolic blood pressure (DBP) at 7 years of age, and a mean decrease of 0.62 mmHg for SBP and 1.04 mmHg for DBP at 7 years of age. Compared with children born to mothers without aspirin exposure, those whose mothers were exposed to aspirin for at least 7 days during pregnancy had approximately 10% and 27% reduced risk of high SBP and DBP, respectively, and a mean reduction of 0.61 and 1.27 mmHg in SBP and DBP at 7 years of age. The earlier the aspirin exposure occurred during pregnancy, the lower the risk of childhood high blood pressure. Conclusion In utero exposure to aspirin may have long-term benefits for childhood blood pressure.