Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence
Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence
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DOI：
10.1016/j.biopsych.2003.07.007
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发表时间：
2004-02-01
影响因子：
10.6
通讯作者：
Frost, JJ
中科院分区：
文献类型：
--
作者：
Bencherif, B;Wand, GS;Frost, JJ
背景：通过动物和人体研究，内源性阿片系统与酒精依赖有关。我们探讨了酒精依赖受试者中酒精渴求与脑μ阿片受体（R-OR）的关系。方法：采用[C-11]卡芬太尼正电子发射断层扫描技术，测定了8名男性酒精依赖受试者和8名匹配的对照受试者的局部脑μ阿片受体结合电位（BP）。自我报告的酒精渴望，戒断和情绪进行了测量。较低的mu-OR血压与右背外侧前额叶皮层、右前额叶皮层和右顶叶皮层的较高渴望相关。在这些地区，酗酒者的平均mu-OR血压低于对照组。其他四个脑区的Mu-OR BP也与渴望相关，但受体结合电位没有组间差异。Mu-OR BP也与抑郁症状在五个脑区，其中三个被确定在渴望analysis.Conclusions：结果表明，酒精的渴望，情绪和R-OR结合在特定的大脑区域最近禁欲，酒精依赖的男性之间有很强的功能关系。
Background: The endogenous opioid system has been linked to alcohol dependence through animal and human studies. We investigated the relationship between alcohol craving and brain mu opioid receptors (R-OR) in alcohol-dependent subjects.Methods: Regional brain mu-OR binding potential (BP) was measured using [C-11]carfentanil positron emission tomography in eight male alcohol-dependent subjects undergoing alcohol withdrawal and eight matched control subjects. Self-reported alcohol craving, withdrawal, and mood were measured.Results. Lower mu-OR BP was associated with higher craving in the right dorsal lateral prefrontal cortex, the fight anterior frontal cortex, and right parietal cortex. In these regions, alcoholics showed lower mean mu-OR BP compared with control subjects. Mu-OR BP in four other brain regions also correlated with craving, but there were no group differences in receptor binding potential. Mu-OR BP also correlated with depressive symptoms in five brain regions, three of which were identified in the craving analyses.Conclusions: Results show a strong functional relationship between alcohol craving, mood, and R-OR binding in specific brain regions of recently abstinent, alcohol-dependent men.