Role of UV light in photodamage, skin aging, and skin cancer: importance of photoprotection.
Role of UV light in photodamage, skin aging, and skin cancer: importance of photoprotection.
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DOI：
10.2165/0128071-200910001-00004
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发表时间：
2009-01-01
影响因子：
7.3
通讯作者：
Gonzaga, Evelyn R
中科院分区：
文献类型：
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作者：
Gonzaga, Evelyn R
太阳辐射，特别是紫外线辐射，会导致分子和细胞损伤，导致组织病理学和临床退行性变化，进而导致光敏、光老化和皮肤癌。虽然我们的身体有一些天然的紫外线防御能力，但额外的防晒是必不可少的，包括躲避阳光、物理保护和使用防晒霜。避免日晒包括在紫外线高峰期(上午10点至下午4点)限制暴露，避免沙子、雪和水等能反射紫外线的表面，以及取消光敏药物。物理防护包括穿着防光服，如宽边帽子和长袖，以及在窗户上使用防紫外线薄膜。含有阿夫苯宗、二氧化钛、氧化锌或胶囊的防晒霜应该每天使用，并经常重复使用。为了防止UVB光谱，特别推荐使用氧化锌和二氧化钛。防晒霜的使用量通常只有推荐量的25%，严重影响了对光的保护。剂量指南建议在头颈部和手臂各用半茶匙以上，躯干前部、躯干后部和腿部各用1茶匙以上(约2毫克/厘米(2))。
Solar, and particularly UV, radiation causes molecular and cellular damage with resultant histopathologic and clinical degenerative changes, leading in turn to photosensitivity, photo-aging, and skin cancer. While our bodies have some natural UV defenses, additional protection from the sun is essential, including sun avoidance, physical protection, and sunscreen use. Sun avoidance includes limiting exposure during peak UV times (10am-4pm), avoiding UV-reflective surfaces such as sand, snow and water, and eliminating photosensitizing drugs. Physical protection includes wearing photoprotective clothing such as a broad-brimmed hat and long sleeves and use of UV-blocking films on windows. Sunscreen containing avobenzone, titanium dioxide, zinc oxide or encamsule should be used daily and frequently reapplied. To guard against the UVB spectrum, zinc oxide and titanium dioxide are particularly recommended. Sunscreen is generally under-applied at only 25% of the recommended dose, seriously compromising photoprotection. Dosage guidelines recommend using more than half a teaspoon each on head and neck area and each arm, and more than a teaspoon each on anterior torso, posterior torso, and each leg (approximately 2 mg/cm(2)).