SURFACE MODIFICATION OF POLYMERIC BIOMATERIALS WITH POLY(ETHYLENE OXIDE), ALBUMIN, AND HEPARIN FOR REDUCED THROMBOGENICITY
SURFACE MODIFICATION OF POLYMERIC BIOMATERIALS WITH POLY(ETHYLENE OXIDE), ALBUMIN, AND HEPARIN FOR REDUCED THROMBOGENICITY
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DOI：
10.1163/156856293x00537
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发表时间：
1993-01-01
影响因子：
3.6
通讯作者：
PARK, K
中科院分区：
文献类型：
--
作者：
AMIJI, M;PARK, K
适当的表面改性可以显著提高高分子生物材料的血液相容性。本文综述了水溶性高分子如聚氧化乙烯（PEO）、白蛋白、肝素等的表面改性方法。PEO是一种合成的中性水溶性聚合物，而白蛋白和肝素分别是一种天然球状蛋白和一种阴离子多糖。当接枝到表面上时，所有三种大分子都具有降低生物材料的血栓形成性的共同特征。降低的血栓形成是由于接枝的大分子的独特的流体动力学性质。在水介质中，表面结合的水溶性聚合物被期望是高度柔性的并且延伸到本体溶液中。接枝有PEO、白蛋白或肝素的生物材料能够主要通过空间排斥机制抵抗血浆孔蛋白吸附和血小板粘附。
Appropriate surface modification has significantly improved the blood compatibility of polymeric biomaterials. This article reviews methods of surface modification with water-soluble polymers, such as polyethylene oxide (PEO), albumin, and heparin. PEO is a synthetic, neutral, water-soluble polymer, while albumin and heparin are a natural globular protein and an anionic polysaccharide, respectively. When grafted onto the surface, all three macromolecules share a common feature to reduce thrombogenicity of biomaterials. The reduced thrombogenicity is due to the unique hydrodynamic properties of the grafted macromolecules. In aqueous medium, surface-bound water-soluble polymers are expected to be highly flexible and extend into the bulk solution. Biomaterials grafted with either PEO, albumin, or heparin are able to resist plasma porotein adsorption and platelet adhesion predominantly by a steric repulsion mechanism.