OPTIC-NERVE DAMAGE IN HUMAN GLAUCOMA .2. THE SITE OF INJURY AND SUSCEPTIBILITY TO DAMAGE
OPTIC-NERVE DAMAGE IN HUMAN GLAUCOMA .2. THE SITE OF INJURY AND SUSCEPTIBILITY TO DAMAGE
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DOI：
10.1001/archopht.1981.03930010635009
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发表时间：
1981-01-01
影响因子：
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通讯作者：
MAUMENEE, AE
中科院分区：
文献类型：
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作者：
QUIGLEY, HA;ADDICKS, EM;MAUMENEE, AE
对9例(15眼)有青光眼病史的患者进行了视神经头的组织学结构检查。所有人都看到了眼睛，从正常的视力和视野到严重的青光眼损害。神经纤维受损的部位是巩膜筛板，在那里有轴突运输的局部阻塞。在确定的视野消失之前，早期视杯大小的增加是由于神经纤维的丢失，而不是由于神经头的星形胶质细胞的损伤。在轻度损伤的标本中，没有发现对神经头毛细血管的选择性损伤。扫描电子显微镜分析表明，筛板的结构是决定眼压升高损伤易感性程度的重要因素。
The histologic structure of the optic nerve head was examined in 15 eyes of 9 persons with a known glaucoma history. All had been seeing eyes, varying from normal visual acuity and visual field to advanced glaucoma damage. The site of damage to nerve fibers is the scleral lamina cribrosa, where there is local blockage of axonal transport. Early cup size increase prior to definite field loss results from loss of nerve fibers, not from damage to astrocytic glial cells of the nerve head. No selective damage to nerve head capillaries is seen in mildly damaged specimens. Scanning electron microscopic analysis suggests that the structure of the lamina cribrosa is an important determinant of the degree of susceptibility to damage by elevated intraocular pressure.