Basal-like carcinoma of the breast: Further evidence of the possibility that most metaplastic carcinomas may be actually basal-like carcinomas
Basal-like carcinoma of the breast: Further evidence of the possibility that most metaplastic carcinomas may be actually basal-like carcinomas
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DOI：
10.1007/s00795-007-0379-2
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发表时间：
2008-06-01
影响因子：
1.8
通讯作者：
Lee, Gang-Hong
中科院分区：
文献类型：
--
作者：
Kuroda, Naoto;Fujishima, Nokiaki;Lee, Gang-Hong
一些研究人员此前曾提出，基底样癌可能由浸润性导管癌（未另有说明）、化生性癌和髓样癌的成分组成。我们在此报告两例显示基底细胞/肌上皮分化的乳腺癌病例。第一个病例是一名58岁的日本女性，第二个病例是一名39岁的日本女性。这两种肿瘤均由粘液物质背景上的上皮细胞和/或梭形或星状细胞增殖组成。此外，在第一例的转移病灶和第二例的原发灶中观察到软骨样基质。免疫组织化学显示，上皮肿瘤细胞的 E-钙粘蛋白和细胞角蛋白 CAM5.2 呈阳性，上皮细胞和梭形或星状细胞的细胞角蛋白 5、14 或 17、α-平滑肌肌动蛋白、S-100 和 p63 呈阳性。我们的结果提供了进一步的证据，表明大多数化生性癌实际上可能是基底样癌。
Some investigators have previously suggested that basal-like carcinoma may consist of components of invasive ductal carcinoma, not otherwise specified, metaplastic carcinoma, and medullary carcinoma. We report here two cases of breast carcinoma showing basal cell/myoepithelial differentiation. The first case was a 58-year-old Japanese woman and the second case was a 39-year-old Japanese woman. The two tumors were composed of the proliferation of epithelial cells and/or spindle-or stellate-shaped cells on the background of mucinous materials. Additionally, chondroid matrix was observed in the metastatic lesion of the first case and the primary lesion of the second case. Immunohistochemically, epithelial neoplastic cells were positive for E-cadherin and cytokeratin CAM5.2, and epithelial and spindle-or stellate-shaped cells were positive for cytokeratins 5, 14, or 17, alpha-smooth muscle actin, S-100, and p63. Our results supply further evidence that most metaplastic carcinomas may be actually be basallike carcinomas.