Survival Rate of Intrahepatic Cholangiocarcinoma Patients after Surgical Treatment in Thailand
Survival Rate of Intrahepatic Cholangiocarcinoma Patients after Surgical Treatment in Thailand
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DOI：
10.7314/apjcp.2013.14.2.1107
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发表时间：
2013-01-01
影响因子：
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通讯作者：
Kamsaard, Supot
中科院分区：
文献类型：
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作者：
Sriputtha, Sudarat;Khuntikeo, Narong;Kamsaard, Supot
肝内胆管细胞癌(ICC)是泰国东北部地区常见的原发性肝癌之一。手术切除仍然是最好的治疗方法，但患有ICC的患者通常出现在疾病的晚期。关于手术后生存和预后因素的研究仍然很少。本研究的目的是评价肝内胆管癌术后的存活率及影响存活率的因素。这项研究采用了回溯性队列设计。受试者为连续73名ICC患者，他们在2005-2009年间因手术而住进坤健大学斯利那加林医院。审查日期为2011年12月31日，使用单变量和多变量分析对数据进行评估。术后生存分析采用Kaplan-Meier法，独立预后因素采用Cox比例风险模型。总的随访时间为99人年。死亡总人数为59人，死亡率为每100人年59人。累计1、3、5年生存率分别为52.1%、21.7%、11.2%。中位生存期为12.4个月。单因素分析显示，疾病分期、淋巴结转移、组织学类型、组织学分级和大体分类有统计学意义(p值
Intrahepatic cholangiocarcinoma (ICC), one of the primary liver cancers, is frequent in the northeastern part of Thailand. Surgical resection remains the best method of treatment, but patients suffering from ICC usually present at a late stage of the disease. Studies of survival and prognostic factors after surgery remain rare. The aim here was to evaluate the survival rate and factors affecting the survival of patients with intrahepatic cholangiocarcinoma after surgery. The study used a retrospective cohort design. The subjects were 73 consecutive patients with ICC, who were admitted for surgery to Srinagarind Hospital, Khon Kaen University, during the period 2005-2009. The censoring date was 31 December, 2011, data being evaluated using uni- and multivariate analyses. Postoperative survival analysis was performed by the Kaplan-Meier method, and the Cox proportional hazard model was used to identify independent prognostic factors. The total follow-up time was 99 person-years. The total number of deaths was 59, giving a mortality rate of 59 per 100 person-years. The cumulative 1-, 3-, and 5-year survival rates were 52.1%, 21.7%, and 11.2%, respectively. The median duration of survival after resection was 12.4 months. Univariate analysis revealed stage of disease, lymph node metastasis, histological type, histological grade and macroscopic classification to be statistically significant (p-value