Military Chemical Warfare Agent Human Subjects Testing: Part 1-History of Six-Decades of Military Experiments With Chemical Warfare Agents
Military Chemical Warfare Agent Human Subjects Testing: Part 1-History of Six-Decades of Military Experiments With Chemical Warfare Agents
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DOI：
10.7205/milmed-d-04-8308
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发表时间：
2009-10-01
影响因子：
1.2
通讯作者：
Brown, Mark
中科院分区：
文献类型：
--
作者：
Brown, Mark
从第一次世界大战到1975年，军用化学战剂测试产生了数千名退伍军人，他们担心可能会对健康造成长期影响。对潜在的长期健康影响的临床和研究评估一直很困难，因为暴露发生在几十年前，暴露的部队的身份和暴露的程度不确定，实验期间的急性影响记录不足。相比之下，配套的一篇文章描述了关于测试的特定制剂及其长期健康影响的大量可用信息。这段简短的历史描述了美国军用化学制剂在人体上的实验，并确定了被测试的制剂。最后，参与这类军事测试的军事人员需要预测未来的健康问题，这表明法律和法规应要求当前和未来的军事研究人员全面记录所有受试者的身份、相关的暴露程度和完整的医学信息。新的研究方案和机构审查委员会对涉及军事人员的研究的批准应反映这一需要。
Military chemical warfare agent testing from World War I to 1975 produced thousands of veterans with concerns of possible long-term health consequences. Clinical and research evaluation of potential long-term health effects has been difficult because the exposures occurred decades ago, the identity of troops exposed and exposure magnitudes are uncertain, and acute effects during experiments poorly documented. In contrast, a companion article describes the large amount of information available about the specific agents tested and their long-term health effects. This short history describes U.S. military chemical-agent experiments with human subjects and identifies tested agents. Finally, the demonstrated need to anticipate future health concerns from military personnel involved in such military testing suggests current and future military researchers should be required, by law and regulation, to fully record the identity of those exposed, relevant exposure magnitude, and complete medical information for all subjects. New study protocols and institutional review board approvals for research involving military personnel should reflect this need.