Melatonin reduces motivation for cocaine self-administration and prevents relapse-like behavior in rats
Melatonin reduces motivation for cocaine self-administration and prevents relapse-like behavior in rats
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DOI：
10.1007/s00213-017-4576-y
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发表时间：
2017-06-01
影响因子：
3.4
通讯作者：
Spanagel, Rainer
中科院分区：
文献类型：
--
作者：
Takahashi, Tatiane T.;Vengeliene, Valentina;Spanagel, Rainer
褪黑激素是一种参与昼夜节律的激素，在吸毒者中出现失调。此外，它已被证明，褪黑激素可以调节几种药物的滥用的增强效果，因此可能发挥作用，在drug addiction.Objective在这里，我们调查是否管理褪黑激素减少复发样行为和动机，以寻求cocaine in rats.Methods雄性Sprague-Dawley大鼠提交长期可卡因自我管理训练。此后，褪黑激素的作用进行了评估：（1）在断点测试中的可卡因工作的动机，（2）在线索诱导的恢复测试中的复发样行为，（3）在开放领域的测试中的距离，和（4）在两瓶选择范例中的蔗糖偏好。褪黑激素，25或50 mg/kg，注射后34 h的黑暗阶段发病，30 min前，每个tests.Results两个剂量的褪黑激素减少了在两个断点和线索诱导的恢复测试中的主动戳的数量，表明褪黑激素可以减少可卡因寻求行为和动机可卡因工作。然而，给予较高剂量的这种激素，显着减少了线索诱导的恢复试验期间的非活动戳的数量，并倾向于减少动物的运动活动在开放领域的测试。蔗糖的偏好是不变的车辆和褪黑激素治疗的动物groups.Conclusions我们的数据表明，褪黑激素管理可能会降低可卡因经验丰富的动物的线索引发复发的风险。
Rationale Melatonin is a hormone involved in the entrainment of circadian rhythms, which appears dysregulated in drug users. Further, it has been demonstrated that melatonin can modulate the reinforcing effects of several drugs of abuse and may therefore play a role in drug addiction.Objective Here, we investigated whether administration of melatonin reduces relapse-like behavior and the motivation to seek cocaine in rats.Methods Male Sprague-Dawley rats were submitted to long-term cocaine self-administration training. Thereafter, melatonin effects were assessed on: (1) the motivation to work for cocaine in the break point test, (2) the relapse-like behavior in the cue-induced reinstatement test, (3) the distance traveled in the open field test, and (4) sucrose preference in a two-bottle choice paradigm. Melatonin, 25 or 50 mg/kg, was injected 34 h after the dark phase onset, 30 min prior to each test.Results Both doses of melatonin decreased the number of active pokes in both break point and cue-induced reinstatement tests, demonstrating that melatonin can reduce the cocaine-seeking behavior and the motivation to work for cocaine. Administration of the higher dose of this hormone, however, significantly reduced the number of inactive pokes during the cue-induced reinstatement test and tended to reduce animals' locomotor activity in the open field test. Sucrose preference was unchanged in both vehicle-and melatonin-treated animal groups.Conclusions Our data suggest that melatonin administration may lower the risk of relapse triggered by cues in cocaine-experienced animals.