Post-translational regulation of the mTORC1 pathway: A switch that regulates metabolism-related gene expression
Post-translational regulation of the mTORC1 pathway: A switch that regulates metabolism-related gene expression
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DOI：
10.1016/j.bbagrm.2024.195005
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发表时间：
2024-01-19
影响因子：
4.7
通讯作者：
Teng，Xinchen
中科院分区：
文献类型：
--
作者：
Wang，Yitao;Engel，Tobias;Teng，Xinchen
雷帕霉素复合体1(MTORC1)的作用靶点是一种激酶复合体，它在协调细胞生长过程中起着至关重要的作用，这些信号包括氨基酸、生长因子、氧和三磷酸腺苷。MTORC1的激活促进了细胞的生长和合成代谢，而它的抑制则导致分解代谢和抑制细胞的生长，使细胞能够抵抗营养缺乏和应激。MTORC1活性的失调与许多疾病有关，如癌症、代谢紊乱和神经退行性疾病。本文就翻译后修饰，特别是磷酸化和泛素化，如何调节mTORC1信号通路及其在发病机制中的意义作一综述。了解磷酸化和泛素化对mTORC1信号通路的影响有助于深入了解细胞生长的调控和相关疾病的潜在治疗靶点。
The mechanistic target of rapamycin complex 1 (mTORC1) is a kinase complex that plays a crucial role in coordinating cell growth in response to various signals, including amino acids, growth factors, oxygen, and ATP. Activation of mTORC1 promotes cell growth and anabolism, while its suppression leads to catabolism and inhibition of cell growth, enabling cells to withstand nutrient scarcity and stress. Dysregulation of mTORC1 activity is associated with numerous diseases, such as cancer, metabolic disorders, and neurodegenerative conditions. This review focuses on how post-translational modifications, particularly phosphorylation and ubiquitination, modulate mTORC1 signaling pathway and their consequential implications for pathogenesis. Understanding the impact of phosphorylation and ubiquitination on the mTORC1 signaling pathway provides valuable insights into the regulation of cellular growth and potential therapeutic targets for related diseases.