[Function and modulation of type Ⅱ innate lymphoid cells and their role in chronic upper airway inflammatory diseases].
[Function and modulation of type Ⅱ innate lymphoid cells and their role in chronic upper airway inflammatory diseases].
复制标题
DOI：
10.3760/cma.j.issn.1673-0860.2017.02.017
复制
发表时间：
2017-02-07
影响因子：
--
通讯作者：
Liu, Z
中科院分区：
文献类型：
--
作者：
Liu, Y;Liu, Z
Ⅱ型先天淋巴样细胞（ILC2）是先天免疫淋巴细胞的一个家族，对细胞因子提供有效的免疫应答。ILC2受核转录因子ROR α、GATA3、分泌细胞因子IL-5、IL-13等调控。动物模型表明ILC2参与了过敏性疾病，如哮喘和特应性皮炎，在代谢平衡中也起着非常重要的作用。此外，最近的报道表明，ILC2不仅在疾病的初始阶段发挥作用，还可导致疾病的慢性病理变化，如纤维化，并可能对获得性免疫产生影响。本文主要就ILC2细胞的作用及调控进行综述，并对ILC2在变应性鼻炎、慢性鼻窦炎等慢性上呼吸道炎症性疾病中的研究现状进行综述。
Type Ⅱ innate lymphoid cells (ILC2) is a family of innate immune lymphocytes, which provide effective immune responses to cytokines. ILC2 are regulated by the nuclear transcription factor ROR alpha and GATA3, secreting cytokines IL-5 and IL-13, etc. Animal models have shown that ILC2 are involved in allergic diseases, such as asthma and atopic dermatitis, and also play a very important role in the metabolic balance. In addition, recent reports suggest that ILC2 not only play a role in the initial stages of the disease, but also can lead to chronic pathological changes in the disease, such as fibrosis, and may have an effect on acquired immunity. This paper mainly focus in the role and regulation of ILC2 cells, and review the research status of ILC2 in the field of chronic upper airway inflammatory diseases including allergic rhinitis and chronic rhinosinusitis.