Evaluation of mass screening for thyroid cancer.
Evaluation of mass screening for thyroid cancer.
复制标题
甲状腺癌大规模筛查的评估。
DOI：
10.1093/oxfordjournals.jjco.a039251
复制
发表时间：
1988
影响因子：
2.4
通讯作者：
K. Satoh
中科院分区：
文献类型：
--
作者：
T. Ishida;M. Izuo;T. Ogawa;J. Kurebayashi;K. Satoh
1980年至1986年，在日本群马县进行了成年妇女甲状腺癌和乳腺癌的大规模筛查。在这七年中，研究对象的总数为152,651人。第一次筛查是由经验丰富的外科医生进行检查和触诊。5902名受试者(3.9%)发现甲状腺异常，3804名受试者(2.5%)需要参加第二次检查。共检出甲状腺癌216人，发现率为0.14%。初次筛查时甲状腺癌的发现率(0.19%)是随后定期筛查时(0.09%)的两倍。甲状腺癌组织学分型：乳头状癌189例(87.5%)，滤泡性癌26例(12%)，髓样癌1例(0.5%)。在筛查时，87%的甲状腺癌是没有症状的。肿瘤直径<2 cm者126例(58.3%)。通过大规模筛查发现的甲状腺癌在早期被发现，与我们通常的门诊患者相比，显示出显著更高的存活率。由于大规模筛查发现分化型癌的发病率较高，该计划有助于甲状腺癌的早期发现和治疗。
Mass screening for detecting both thyroid and breast cancer in adult women was carried out in Gunma Prefecture, Japan, between 1980 and 1986. The total number of subjects during the seven years was 152,651. The first screening was by inspection and palpation using experienced surgeons. Thyroid abnormalities were found in 5,902 subjects (3.9%) and 3,804 (2.5%) were required to attend a second examination. Thyroid carcinoma was detected in a total of 216 subjects, a detection rate of 0.14%. The detection rate for thyroid cancer was twice as high at the initial screening (0.19%) than that at subsequent periodic screenings (0.09%). Histological classifications of the detected thyroid cancers were: papillary carcinoma, 189 cases (87.5%); follicular carcinoma, 26 (12%); medullary carcinoma, 1 (0.5%). Eighty-seven percent of the thyroid cancers were asymptomatic at the time of screening. The tumor size were 2 cm or less in 126 patients (58.3%). Thyroid cancer detected by mass screening was revealed at an earlier stage and showed a significantly better survival rate compared to that of our usual outpatients. As differentiated carcinoma has been found at a higher incidence by mass screening, the program is useful for the early detection and treatment of thyroid cancer.