Syntheses of three terbium complexes as fluorescent probes and their application on the pH detection of routine urine test
Syntheses of three terbium complexes as fluorescent probes and their application on the pH detection of routine urine test
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三种铽配合物荧光探针的合成及其在尿常规pH检测中的应用
DOI：
10.1016/j.cclet.2017.08.037
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发表时间：
2017-10-01
影响因子：
9.1
通讯作者：
Peng, Yu
中科院分区：
文献类型：
--
作者：
Luo, Ai-Min;Shao, Yongliang;Peng, Yu
通过用吸电子或供电子基团修饰水杨酸部分，得到三个新的铽配合物（L-I）。结核病,L-II。结核病,L-III。合成了三足羧酸配体。由于配体的拉推电子效应不同，这些铽配合物的荧光强度变化明显，即：L-II。Tb > L-III。Tb > l - i - Tb。同时，在492 nm处(D-5（4) -> F-7(6)）和547 nm处(D-5（4) -> F-7(5)）的特征峰对各种pH条件均表现出“Off-On-Off”的荧光响应，表明它们都可以作为高灵敏度的pH荧光探针。值得注意的是，使用L-II。Tb作为一种荧光性能最好的探针，可以很容易地通过pH值引发的响应来监测一些患者的尿液样本。因此,L-II。结核在临床实践中具有通过尿常规pH值检测辅助诊断某些疾病的潜力。(C) 2017年中国化学学会，中国医学科学院药物研究所。Elsevier B.V.版权所有。
By modifying the salicylic-acid moiety with electron-withdrawing or-donating groups, three new terbium complexes (L-I.Tb, L-II.Tb, L-III.Tb) based on tripodal carboxylate ligands were synthesized. Due to different pull-push electronic effects of ligands, the fluorescence intensities of these terbium complexes significantly varied, that is: L-II.Tb > L-III.Tb > L-I.Tb. Meanwhile, the characteristic peaks at 492 nm (D-5(4) -> F-7(6)) and 547 nm (D-5(4) -> F-7(5)) showed "Off-On-Off" fluorescence response to various pH conditions, which indicated that all of them can be used as the highly sensitive pH fluorescent probes. Notably, using L-II.Tb with the best fluorescence performance as a probe, some patients' urine samples can be easily monitored through the response triggered by pH value. Therefore, L-II.Tb has the potential to auxiliarily diagnose some diseases in clinical practice through pH detection of routine urine test. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.