The Centrioles, Centrosomes, Basal Bodies, and Cilia of Drosophila melanogaster.
The Centrioles, Centrosomes, Basal Bodies, and Cilia of Drosophila melanogaster.
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DOI：
10.1534/genetics.116.198168
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发表时间：
2017-05
期刊：
影响因子：
3.3
通讯作者：
Glover DM
中科院分区：
文献类型：
--
作者：
Lattao R;Kovács L;Glover DM
中心粒在果蝇的发育中起着关键作用。它们是正确形成中心体所必需的，中心体是纺锤体两极的细胞器，可以作为微管组织中心（MTOCs）持续存在于间期。胞质微管（MTs）成核的能力是周围中心粒周围物质（PCM）的一种特性。中心粒具有双重功能，既是中心体的核心，又是基底，是纤毛和鞭毛形成的模板结构。因此，中心粒、中心体和基体的结构和功能对发育和生理的许多方面都有影响，这些可以很容易地在果蝇身上建立模型。中心体对于组织合胞胚胎中迅速增加的细胞核数量和在许多组织中精确地进行细胞分裂，特别是在雄性减数分裂期间，是必不可少的。尽管有丝分裂细胞周期可以在没有中心体的情况下发生，但这是一个容易出错的过程，使果蝇容易出现发育缺陷和肿瘤形成的可能性。本文综述了黑腹果蝇不同组织和培养细胞中中心粒、中心体和基体的结构和功能，重点介绍了它们在发育和细胞分裂的不同方面的作用。
Centrioles play a key role in the development of the fly. They are needed for the correct formation of centrosomes, the organelles at the poles of the spindle that can persist as microtubule organizing centers (MTOCs) into interphase. The ability to nucleate cytoplasmic microtubules (MTs) is a property of the surrounding pericentriolar material (PCM). The centriole has a dual life, existing not only as the core of the centrosome but also as the basal body, the structure that templates the formation of cilia and flagellae. Thus the structure and functions of the centriole, the centrosome, and the basal body have an impact upon many aspects of development and physiology that can readily be modeled in Drosophila. Centrosomes are essential to give organization to the rapidly increasing numbers of nuclei in the syncytial embryo and for the spatially precise execution of cell division in numerous tissues, particularly during male meiosis. Although mitotic cell cycles can take place in the absence of centrosomes, this is an error-prone process that opens up the fly to developmental defects and the potential of tumor formation. Here, we review the structure and functions of the centriole, the centrosome, and the basal body in different tissues and cultured cells of Drosophila melanogaster, highlighting their contributions to different aspects of development and cell division.