Review of oral cholera vaccines: efficacy in young children.
Review of oral cholera vaccines: efficacy in young children.
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DOI：
10.2147/idr.s10339
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发表时间：
2011
影响因子：
3.9
通讯作者：
Zuckerman JN
中科院分区：
文献类型：
--
作者：
Masuet Aumatell C;Ramon Torrell JM;Zuckerman JN
幼儿是可能感染霍乱的最脆弱群体之一。以下对现有霍乱疫苗有效性的文献综述为临床使用霍乱疫苗提供了明确的证据基础，特别是在疫情情况下。评估口服霍乱疫苗预防幼儿霍乱病例的效果。对1983年至2011年期间的文献进行了系统的回顾，检索词为“口服霍乱疫苗”、“儿童”和“疗效”，仅限于“临床试验”和“人体研究”。口服霍乱疫苗为幼儿提供了可接受的保护水平，免疫后12个月或24个月的保护水平更高。建议暴露于霍乱潜在风险的儿童接种口服霍乱疫苗，无论其成分是否包括B亚基。
Young children are one of the most vulnerable groups who may be infected with cholera. The following literature review of the efficacy of the currently available cholera vaccines provides a clear evidence base for the clinical administration of cholera vaccine, particularly in an epidemic situation. To assess the efficacy of oral cholera vaccines in preventing cases of cholera in young children. A systematic literature review was undertaken for the period 1983 to 2011 using PubMed and the search terms “oral cholera vaccines,” “children,” and “efficacy,” limited to “clinical trials” and “human studies”. Oral cholera vaccine provides an acceptable level of protection in young children, with the level of protection being greater at 12 or 24 months following immunization. Children exposed to a potential risk of cholera are recommended to be vaccinated with an oral cholera vaccine, irrespective of whether its constituents include the B subunit.