Evidence-based guidelines for interpreting change scores for the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30
Evidence-based guidelines for interpreting change scores for the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30
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DOI：
10.1016/j.ejca.2012.02.059
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发表时间：
2012-07-01
影响因子：
8.4
通讯作者：
Brown, J. M.
中科院分区：
文献类型：
--
作者：
Cocks, K.;King, M. T.;Brown, J. M.
目的：利用已发表的文献和专家意见，探讨采用欧洲癌症研究与治疗组织生活质量问卷核心30 （EORTC QLQ-C30）测量的患者组生活质量（QOL）变化的临床意义和程度。方法：采用一种结合已发表研究的系统回顾、专家意见和荟萃分析的创新方法来估计QLQ-C30分数随时间的大、中、小平均变化。结果：共检索论文911篇，检索相关论文118篇。在荟萃分析中合并了1232个生活质量随时间的平均变化，时间尺度从4天到5年不等。指南分别针对普通、小型和中等规模的班级、每个子量表以及分数的提高和下降制定。对改善的估计比各自对下降的估计要小。结论：这些指南可用于帮助计算样本量和解释患者组随时间的平均变化。在大多数临床情况下，观察到的QLQ-C30评分的平均变化通常很小，可能是由于反应转移。在规划主要关注生活质量随时间变化的研究时，需要仔细考虑；随访的时间、样本损耗、生活质量变化的方向和主要兴趣的子量表是关键的考虑因素。(C) 2012 Elsevier Ltd.版权所有。
Aim: To use published literature and experts' opinion to investigate the clinical meaning and magnitude of changes in the Quality of Life (QOL) of groups of patients measured with the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30).Methods: An innovative method combining systematic review of published studies, expert opinions and meta-analysis was used to estimate large, medium, and small mean changes over time for QLQ-C30 scores.Results: Nine hundred and eleven papers were identified, leading to 118 relevant papers. One thousand two hundred and thirty two mean changes in QOL over time were combined in the meta-analysis, with timescales ranging from four days to five years. Guidelines were produced for trivial, small, and medium size classes, for each subscale and for improving and declining scores separately. Estimates for improvements were smaller than respective estimates for declines.Conclusions: These guidelines can be used to aid sample size calculations and interpretation of mean changes over time from groups of patients. Observed mean changes in the QLQ-C30 scores are generally small in most clinical situations, possibly due to response shift. Careful consideration is needed when planning studies where QOL changes over time are of primary interest; the timing of follow up, sample attrition, direction of QOL changes, and subscales of primary interest are key considerations. (C) 2012 Elsevier Ltd. All rights reserved.