INCREASED INTERLEUKIN-6 LEVELS IN CEREBROSPINAL-FLUID FOLLOWING SUBARACHNOID HEMORRHAGE
INCREASED INTERLEUKIN-6 LEVELS IN CEREBROSPINAL-FLUID FOLLOWING SUBARACHNOID HEMORRHAGE
复制标题
DOI：
10.3171/jns.1993.78.4.0562
复制
发表时间：
1993-04-01
影响因子：
4.1
通讯作者：
VONHOLST, H
中科院分区：
文献类型：
--
作者：
MATHIESEN, T;ANDERSSON, B;VONHOLST, H
分析了12例患者的血清和脑脊液（CSF）样本的白细胞介素（IL）-6，可溶性IL-2受体（IL-2 R）和可溶性CD 8水平，以确定蛛网膜下腔出血（SAH）后的免疫激活情况。在12例患者中的11例中检测到CSF中IL-6水平显著升高和可溶性IL-2 R中度升高;在6例患者中观察到可溶性CD 8水平略微升高。第6天的IL-6水平高于第3天和第9天。CSF样本中IL-6、可溶性IL-2 R和可溶性CD 8水平的升高未被血清样本中升高的值所抵消，因此可能反映了细胞因子的鞘内合成。IL-6通过血脑屏障的被动转移似乎没有发生，因为IL-6的血清和CSF水平显示负相关。研究结果提示中枢神经系统存在严重的炎症反应，这对于理解SAH患者的临床病程具有重要意义。
Serum and cerebrospinal fluid (CSF) samples from 12 patients were analyzed for interleukin (IL)-6, soluble IL-2 receptor (IL-2R), and soluble CD8 levels in order to determine the immune activation profile following subarachnoid hemorrhage (SAH). Dramatically increased levels of IL-6 and moderate increases of soluble Il-2R were detected in the CSF in 11 of the 12 patients; slightly elevated levels of soluble CD8 were observed in six patients. The IL-6 levels were higher on Day 6 than on Days 3 and 9. The increases in IL-6, soluble IL-2R, and soluble CD8 levels in the CSF samples were not paralleled by increased values in the serum samples, and thus probably reflected an intrathecal synthesis of the cytokine. Passive transfer of IL-6 across the blood-brain barrier seemed not to occur since the serum and CSF levels of IL-6 showed a negative correlation. The findings suggest a severe inflammatory affection of the central nervous system that could be of importance in understanding the clinical course in patients following SAH.