Simulation of freezing step in vial lyophilization using finite element method
Simulation of freezing step in vial lyophilization using finite element method
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DOI：
10.1016/j.compchemeng.2010.10.009
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发表时间：
2011-11-15
影响因子：
4.3
通讯作者：
Dini, Nicolas G.
中科院分区：
文献类型：
--
作者：
Muzzio, Cristian R.;Dini, Nicolas G.
确定冷冻过程中的传热和温度分布是预测冻干产品最终结构的基础。本研究的目的是建立和优化基于有限元方法的冻结过程动力学模型，以研究最终产品在垂直方向和径向的形态。考虑了不同的因素：腔室压力、货架温度、小瓶形状、初始溶液温度、成核温度和相变。提出的动态轴对称模型可以模拟瓶内各点的温度和液固界面的位置，而不需要对参数进行拟合，也不需要可疑的假设。此外，将该模型扩展到预测各元素的平均晶体尺寸，并考察了不同因素的影响。(C)2010爱思唯尔有限公司。保留所有权利。
Determination of heat transfer and temperature profile during freezing step is fundamental to predict the final structure of a lyophilized product. The aim of this study was to develop and optimize a dynamic model based on finite element method for simulation of freezing step in order to study final product morphology in both vertical and radial directions. Different factors have been taken into account: chamber pressure, shelf temperature, vial shape, initial solution temperature, nucleation temperature and phase changes. The dynamic axisymmetric model proposed could simulate temperature of each point in the vial and position of liquid-solid interface, without necessity of fitting parameters or questionable assumptions. In addition, the model was extended to predict the average crystal size in each element and the influence of different factors was examined. (C) 2010 Elsevier Ltd. All rights reserved.