The tumor microenvironment: a pitch for multiple players.
The tumor microenvironment: a pitch for multiple players.
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DOI：
10.3389/fonc.2013.00090
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发表时间：
2013
影响因子：
4.7
通讯作者：
Mattei F
中科院分区：
文献类型：
--
作者：
Schiavoni G;Gabriele L;Mattei F
癌症微环境在概念上可以被视为一个球场，其中主要参与者是常驻和非常驻细胞成分，每个细胞成分都涵盖了一个定义的角色，并通过可溶性介质的复杂网络相互连接。这些细胞和肿瘤细胞在这种环境中的相互作用决定了肿瘤进展的命运。渗透到肿瘤床的免疫细胞通过血液循环运送到那里，并发挥多种作用，要么抵消要么有利于肿瘤生长。在这里，我们回顾和讨论了组成肿瘤床的多个群体，特别关注免疫细胞亚群，积极或消极地决定肿瘤的进展。在这种情况下，也将讨论肿瘤微环境中癌症干细胞的贡献。最后，我们说明了新的综合方法，在体外研究肿瘤微环境的最新进展。
The cancer microenvironment may be conceptually regarded as a pitch where the main players are resident and non-resident cellular components, each covering a defined role and interconnected by a complex network of soluble mediators. The crosstalk between these cells and the tumor cells within this environment crucially determines the fate of tumor progression. Immune cells that infiltrate the tumor bed are transported there by blood circulation and exert a variety of effects, either counteracting or favoring tumor outgrowth. Here, we review and discuss the multiple populations composing the tumor bed, with special focus on immune cells subsets that positively or negatively dictate neoplastic progression. In this scenario, the contribution of cancer stem cells within the tumor microenvironment will also be discussed. Finally, we illustrate recent advances on new integrated approaches to investigate the tumor microenvironment in vitro.