The comparative metabolism of 2-bromoethanol and ethylene oxide in the rat.
The comparative metabolism of 2-bromoethanol and ethylene oxide in the rat.
复制标题
2-溴乙醇和环氧乙烷在大鼠体内的代谢比较。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
G. Wells
中科院分区：
文献类型：
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作者：
A. Jones;G. Wells
1. 研究了2-溴[U-14C]乙醇和[U-14C]环氧乙烷在大鼠体内的代谢。2. 由于这两种化合物产生相似数量的两种尿液代谢物，鉴定为S-（2-羟乙基）半胱氨酸和n -乙酰基-S-（2-羟乙基）半胱氨酸，因此提出2-溴乙醇在体内转化为环氧乙烷。3. 2-溴乙醇的一个次要代谢产物已被鉴定为n -乙酰- s -（羧甲基）半胱氨酸。4. 研究了溴乙醛和溴乙酸的代谢；n -乙酰- s -（羧甲基）半胱氨酸已被证明是一种常见的尿代谢物。5. 提出了2-溴乙醇经溴乙醛和溴乙酸氧化代谢为n -乙酰- s -（羧甲基）半胱氨酸的途径。
1. The metabolism of 2-bromo[U-14C]ethanol an [U-14C]ethylene oxide has been studied in the rat. 2. As both compounds give rise to similar amounts of two urinary metabolites, identified as S-(2-hydroxyethyl)cysteine and N-acetyl-S-(2-hydroxyethyl)cysteine, it is proposed that 2-bromoethanol is converted into ethylene oxide in vivo. 3. A minor metabolite of 2-bromoethanol has been identified as N-acetyl-S-(carboxymethyl)cysteine. 4. The metabolism of bromoacetaldehyde and bromoacetic acid has been investigated; N-acetyl-S-(carboxymethyl)cysteine had been shown to be a common urinary metabolite. 5. An oxidative metabolic pathway is proposed for 2-bromoethanol, via bromoacetaldehyde and bromoacetic acid, to N-acetyl-S-(carboxymethyl)cysteine.