Neuro anatomic Pathways Associated with Poststroke Affective and Apathetic Depression
Neuro anatomic Pathways Associated with Poststroke Affective and Apathetic Depression
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DOI：
10.1016/j.jagp.2013.01.057
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发表时间：
2013-09-01
影响因子：
7.2
通讯作者：
Kurisu, Kaoru
中科院分区：
文献类型：
--
作者：
Murakami, Taro;Hama, Seiji;Kurisu, Kaoru
目的：我们的目标是利用磁共振成像定位脑卒中后抑郁症患者的病变，基于统计参数图图像分析技术，该技术可用于组合来自多个参与者的图像数据，并将这些图像与其他数据集相关联。方法：对149例脑卒中后患者进行磁共振成像采集，分别使用医院焦虑抑郁量表和冷漠量表评估情感和冷漠症状。我们创建了一个统计参数图，显示病变位置与情感和冷漠症状之间的关联。结果：抑郁评分较高的患者，病变重叠部位以脑干、左侧基底节和左侧额叶皮层为中心。在冷漠得分较高的患者中，病变重叠以脑干和双侧纹状体为中心。情感性抑郁和麻木性抑郁的重叠病变主要集中在脑干；然而，这两种类型的抑郁症通常不会重叠。结论：卒中后可能出现的两种核心症状，情感性和麻木症状，似乎与不同的单胺能神经解剖通路（血清素能和多巴胺能）有关。
Objectives: Our goal was to localize lesions in poststroke depression patients using magnetic resonance imaging, based on the statistical parametric maps image analysis technique that can be used to combine image data from multiple participants and correlate these images with other data sets. Methods: Magnetic resonance imaging acquisitions were obtained from 149 poststroke patients, who were assessed for affective and apathetic symptoms using the Hospital Anxiety and Depression Scale and the Apathy Scale, respectively. We created a statistical parametric map that displayed an association between lesion location and affective and apathetic symptoms. Results: Among the patients with higher depressive scores, the lesion overlap centered on the brainstem, left basal ganglia, and left frontal cortex. Among the patients with higher apathy scores, the lesion overlap centered on the brainstem and bilateral striatum. The overlap lesion for both affective and apathetic depression centered mainly on the brainstem; however, the two types of depression often did not overlap. Conclusions: Two core symptoms that can occur after stroke, affective and apathetic symptoms, appear to be associated with different monoaminergic neuroanatomic pathways (serotonergic and dopaminergic).