Therapeutic strategies against inflammation and bone loss associated with osteomyelitis.
Therapeutic strategies against inflammation and bone loss associated with osteomyelitis.
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发表时间：
2007-11
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通讯作者：
I. Marriott;Jeremy Miller;Mahnaz Sahraei
中科院分区：
文献类型：
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作者：
I. Marriott;Jeremy Miller;Mahnaz Sahraei
尽管有目前的治疗策略，骨髓炎通常是难治性和复发性的。导致骨髓炎的细菌可以入侵成骨细胞，成骨细胞是感染部位破坏性炎症和骨丢失的积极参与者。因此，慢性骨感染的治疗需要在抑制炎症的同时促进细胞免疫反应的策略。本文综述了常驻骨细胞感知细菌、将白细胞聚集到感染部位和促进破骨细胞介导的骨破坏的机制，以及这些过程的治疗干预的新靶点。
Despite current treatment strategies, osteomyelitis is often refractory and recurrent. The bacteria responsible for osteomyelitis can invade bone-forming osteoblasts, which are active participants in the generation of damaging inflammation and bone loss at sites of infection. Therefore, strategies promoting cell-mediated immune responses while limiting inflammation are required for the treatment of chronic bone infections. This review describes the mechanisms utilized by resident bone cells to perceive bacteria, recruit leukocytes to sites of infection and promote osteoclast-mediated bone destruction, as well as novel targets for the therapeutic intervention of these processes.