Myocardial Extracellular Volume by Cardiac Magnetic Resonance Imaging in Patients Treated With Anthracycline-Based Chemotherapy
Myocardial Extracellular Volume by Cardiac Magnetic Resonance Imaging in Patients Treated With Anthracycline-Based Chemotherapy
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DOI：
10.1016/j.amjcard.2012.11.022
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发表时间：
2013-03-01
影响因子：
2.8
通讯作者：
Jerosch-Herold, Michael
中科院分区：
文献类型：
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作者：
Neilan, Tomas G.;Coelho-Filho, Otavio R.;Jerosch-Herold, Michael
我们的目的是确定是否心肌细胞外容积（ECV），使用心脏磁共振成像期间获得的T1测量测量增加蒽环类药物治疗的患者。我们对42例接受蒽环类药物治疗的患者进行了心脏磁共振成像和超声心动图检查，并测量了ECV。心脏磁共振研究的数据与健康志愿者的数据进行了比较。蒽环类药物治疗队列包括21名男性和21名女性，平均年龄55 ± 17岁，化疗后中位数为84个月，累积蒽环类药物暴露量为282 ± 65 mg/m2，平均左心室射血分数为52 ± 12%。与年龄和性别匹配的对照组相比，蒽环类药物治疗组的ECV升高（0.36 ± 0.03 vs 0.28 ± 0.02，p
We aimed to determine whether the myocardial extracellular volume (ECV), measured using T1 measurements obtained during cardiac magnetic resonance imaging were increased in patients treated with anthracyclines. We performed cardiac magnetic resonance imaging and echocardiography and measured the ECV in 42 patients treated with anthracyclines. The data from the cardiac magnetic resonance study were compared to those from healthy volunteers. The anthracycline-treated cohort consisted of 21 men and 21 women with a mean age of 55 +/- 17 years, who presented a median of 84 months after chemotherapy with a cumulative anthracycline exposure of 282 +/- 65 mg/m(2) and a mean left ventricular ejection fraction of 52 +/- 12%. The ECV was elevated in the anthracycline-treated patients compared to the age- and gender-matched controls (0.36 +/- 0.03 vs 0.28 +/- 0.02, p