A new qualitative interleukin-6 bedside test can predict pneumonia in patients with severe head injury -: Comparison to the standard immulite test and a semiquantitative bedside test
A new qualitative interleukin-6 bedside test can predict pneumonia in patients with severe head injury -: Comparison to the standard immulite test and a semiquantitative bedside test
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DOI：
10.1097/01.ana.0000211026.18926.89
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发表时间：
2007-01-01
影响因子：
3.7
通讯作者：
Woiciechowsky, Christian
中科院分区：
文献类型：
--
作者：
Schlosser, Hans-Georg;Volk, Hans-Dieter;Woiciechowsky, Christian
重型颅脑损伤（SHI）导致全身免疫抑制，这是由中枢机制处理，并与肺炎的高风险。及时识别SHI患者的免疫抑制状况可能有助于通过改变重症监护策略来预防感染。这项前瞻性研究的目的是评估一种识别免疫抑制和预测肺炎的新方法。我们将标准试验（Immulite）测定的白细胞介素（IL）-6水平与使用新床边试验（PicoScan）获得的白细胞介素（IL）-6水平与SHI患者肺炎的发生相关。32例孤立性SHI患者进行了调查。对创伤后2至24小时采集的血清样品进行分析。PicoScan与Immulite测定的IL-6值的Pearson相关系数为0.924（P < 0.001），目视判读与Immulite测定的斯皮尔曼p为0.572（P=0.01）。Immulite和PicoScan的阳性预测值分别为91%和100%，阴性预测值分别为76%和86%。本研究首次研究了PicoScan对患者IL-6浓度的测定。我们的研究结果显示与标准Immulite测试结果具有良好的相关性，并表明PicoScan可用作预测SHI患者肺炎的方便工具。
Severe head injury (SHI) leads to systemic immunosuppression, which is processed by central mechanisms and is associated with a high risk of pneumonia. The timely identification of an immunodepressed condition in SHI patients might help prevent infections by changing the intensive care strategy. The aim of this prospective study is to evaluate a new method for identifying immunodepression and predicting pneumonia. We correlated interleukin (IL)-6 levels determined by the standard test (Immulite) and performed by specialized laboratories with those obtained using the new bedside test (PicoScan) with the occurrence of pneumonia in patients with SHI. Thirty-two patients with isolated SHI were investigated. Analyses were performed on serum samples taken 2 to 24 hours after trauma. Pearson correlation coefficient was 0.924 (P < 0.001) for IL-6 values determined by PicoScan versus Immulite and Spearman p was 0.572 for visual interpretation versus Immulite (P=0.01). Immulite and PicoScan have a positive predictive value of 91% and 100%, respectively, and a negative predictive value of 76% and 86%. The present study investigated for the first time the determination of IL-6 concentrations by PicoScan in patients. Our findings show a good correlation with the results of the standard Immulite test and suggest that the PicoScan may be used as a handy tool to predict pneumonia in SHI patients.