Vitamin D and inflammation: evaluation with neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio.
Vitamin D and inflammation: evaluation with neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio.
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DOI：
10.5114/aoms.2015.50625
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发表时间：
2016-08-01
期刊：
影响因子：
--
通讯作者：
Polat M
中科院分区：
文献类型：
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作者：
Akbas EM;Gungor A;Ozcicek A;Akbas N;Askin S;Polat M
除了经典的骨代谢紊乱外，维生素D、炎症和内皮功能障碍之间的关系可能解释了许多与维生素D缺乏相关的疾病的发病机制。虽然大量报告支持维生素D与炎症的关系，但有几份报告未能证实这种关系。中性粒细胞/淋巴细胞比率(NLR)和血小板/淋巴细胞比率(PLR)是新的、廉价的炎症标志物，可在所有中心进行研究。本研究的目的是通过新的炎症标志物NLR和PLR来研究25-羟基维生素D(25(OH)D)与炎症之间的关系。本研究采用回顾性研究方法。同时进行25(OH)D，记录甲状旁腺激素、白蛋白、钙、磷、碱性磷酸酶、肌酐水平及全血细胞计数。4120名患者的数据被纳入研究。维生素D缺乏组与非维生素D缺乏组之间的PLR(p<；0.001)和NLR值(p=0.001)有显著差异。维生素D与PLR(p<；0.001)和NLR(p<；0.001)呈显著负相关。多元回归分析显示，25(OH)D与PLR独立负相关(OR=0.994，95%CI 0.991~0.998，P=0.02)。血小板/淋巴细胞比率和NLR与25(OH)D水平显著相关，PLR被发现是25(OH)D水平的独立预测因子。我们的研究显示，维生素D水平和炎症与这些廉价且普遍可用的标记物呈负相关。
Association of vitamin D, inflammation and endothelial dysfunction, beside the classic bone metabolism disorders, may explain the pathogenesis of numerous diseases associated with vitamin D deficiency. While large numbers of reports support the relationship of vitamin D with inflammation, several reports fail to confirm this relationship. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are novel and inexpensive markers of inflammation that can be studied in all centers. The goal of this study was to investigate the association between 25-hydroxy vitamin D (25(OH)D) and inflammation with the novel inflammatory markers NLR and PLR. This study was performed retrospectively. Results of the simultaneously performed 25(OH)D, parathyroid hormone, albumin, calcium, phosphorus, alkaline phosphatase and creatinine level measurements and complete blood count were recorded. The data of 4120 patients were included in the study. Between vitamin D deficient and non-deficient groups there were significant differences in PLR (p < 0.001) and NLR (p = 0.001). Vitamin D had a significant negative correlation with PLR (p < 0.001) and NLR (p < 0.001). Multiple regression analysis indicated that 25(OH)D was independently and negatively correlated with PLR (OR = 0.994, 95% CI 0.991–0.998, p = 0.02). Platelet-to-lymphocyte ratio and NLR were significantly associated with 25(OH)D levels, and PLR was found to be an independent predictor of 25(OH)D levels. Our study revealed an inverse association of vitamin D levels and inflammation with these inexpensive and universally available markers.