High fat feeding of lactating mice causing a drastic reduction in fat and energy content in milk without affecting the apparent growth of their pups and the production of major milk fat globule membrane components MFG-E8 and butyrophilin (Retracted Article)
High fat feeding of lactating mice causing a drastic reduction in fat and energy content in milk without affecting the apparent growth of their pups and the production of major milk fat globule membrane components MFG-E8 and butyrophilin (Retracted Article)
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DOI：
10.1271/bbb.63.1749
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发表时间：
1999-10-01
影响因子：
1.6
通讯作者：
Matsuda, T
中科院分区：
文献类型：
--
作者：
Aoki, N;Yamaguchi, Y;Matsuda, T
哺乳期小鼠喂食低脂或高脂饮食。收集牛奶样品并检查其组成。高脂组的甘油三酯和游离脂肪酸含量显著降低，而蛋白质和乳糖含量在两组之间几乎相同。虽然高脂饲料组乳中各成分的能量含量也较低，但两组乳仔的生长发育无显著差异。这种差异可能部分地由一种假设来解释，即幼犬可能会监测牛奶中的卡路里含量，并一直吮吸，直到能量摄入达到他们的满意程度。此外，几乎相同量的主要乳脂肪球膜蛋白MFG-E8和亲丁酸蛋白显示存在于来自两个饮食组的乳中，并且乳腺中两种蛋白质的基因表达也不可区分，这表明主要MFGM组分的产生不仅仅与脂肪产生和分泌有关。
Lactating mice were fed either a low fat or a high fat diet. Milk samples were collected and the composition was examined. Triglyceride and free fatty acid contents were greatly reduced in the milks of high fat diet group, while protein and lactose contents were almost the same between both diet groups. Although the energy content of each component was also lower in milk of high fat diet group, there was apparently no significant difference in the growth of the pups raised by either diet group. This discrepancy might be in part explained by a hypothesis that the pups might monitor calorie content ill milk and keep suckling until the energy intake reaches their satisfaction. Moreover, nearly the same amounts of major milk fat globule membrane proteins MFG-E8 and butyrophilin were shown to be present in the milks from both diet groups and gene expression of both proteins in the mammary glands were also indistinguishable, suggesting that production of major MFGM components is not simply related to fat production and secretion.